TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 272.259 | Formula: C13H12N4O3
H donors: 3 H acceptors: 4 LogP: 1.22 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cc1c(C)[nH]n(c1=O)c1nc2c([nH]1)cccc2
InChi: 1S/C13H12N4O3/c1-7-8(6-11(18)19)12(20)17(16-7)13-14-9-4-2-3-5-10(9)15-13/h2-5,16H,6H2,1H3,(H,14,15)(H,18,19)
InChiKey: VTXCVEGDKYTZPT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	alkB, alkylation repair homolog 3 (E. coli)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Conserved hypothetical protein	Get druggable targets OG5_134523	All targets in OG5_134523
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_134523	All targets in OG5_134523
Mycobacterium leprae	Conserved hypothetical protein	Get druggable targets OG5_134523	All targets in OG5_134523

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G-protein coupled receptor	0.0069	0.2786	1
Brugia malayi	ORL1-like opioid receptor	0.0069	0.2786	1
Echinococcus granulosus	fmrfamide receptor	0.0069	0.2786	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0069	0.2786	1
Schistosoma mansoni	neuropeptide receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	g protein coupled receptor	0.0069	0.2786	1
Schistosoma mansoni	opsin-like receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0069	0.2786	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.1198	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	orexin receptor type 2	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0149	0.0536
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.2786	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.2786	1
Brugia malayi	neuropeptide F receptor	0.0069	0.2786	1
Schistosoma mansoni	biogenic amine receptor	0.0069	0.2786	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.1305	0.4682
Echinococcus granulosus	sex peptide receptor	0.0069	0.2786	1
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.2786	1
Echinococcus multilocularis	somatostatin receptor	0.0069	0.2786	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0069	0.2786	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0069	0.2786	1
Brugia malayi	G protein-coupled receptor	0.0069	0.2786	1
Echinococcus granulosus	G protein coupled receptor 139	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0149	0.0536
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Schistosoma mansoni	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.023	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0069	0.2786	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0069	0.2786	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.2786	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.2786	1
Echinococcus multilocularis	neuropeptide receptor	0.0069	0.2786	1
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.2786	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0069	0.2786	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	adenoreceptor	0.0069	0.2786	1
Echinococcus granulosus	allatostatin A receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	Dopamine receptor protein 2	0.0069	0.2786	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.1305	0.4682
Echinococcus granulosus	g protein coupled receptor	0.0069	0.2786	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.2786	1
Echinococcus multilocularis	serotonin receptor	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.2786	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1454	0.5218
Echinococcus granulosus	neuropeptide receptor	0.0069	0.2786	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	G-protein coupled receptor	0.0069	0.2786	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.1198	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0069	0.2786	1
Schistosoma mansoni	neuropeptide receptor	0.0069	0.2786	1
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0149	0.0536
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.2786	1
Brugia malayi	Serotonin receptor	0.0069	0.2786	1
Mycobacterium ulcerans	hypothetical protein	0.023	1	0.5
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0069	0.2786	1
Schistosoma mansoni	neuropeptide receptor	0.0069	0.2786	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	hypothetical protein	0.0069	0.2786	1
Brugia malayi	GnHR receptor homolog	0.0069	0.2786	1
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Schistosoma mansoni	biogenic amine receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0069	0.2786	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Onchocerca volvulus		0.0069	0.2786	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0069	0.2786	1
Schistosoma mansoni	amine GPCR	0.0069	0.2786	1
Schistosoma mansoni	myosin xvIII	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	follicle stimulating hormone receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	Serotonin receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0069	0.2786	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.109	0.3911
Brugia malayi	putative neuropeptide receptor NPR1	0.0069	0.2786	1
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.2786	1
Brugia malayi	Melatonin receptor type 1A	0.0069	0.2786	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	neuropeptide receptor	0.0069	0.2786	1
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.2786	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	neuropeptide s receptor	0.0069	0.2786	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.2786	1
Schistosoma mansoni	opsin-like receptor	0.0069	0.2786	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0069	0.2786	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1454	0.5218
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.2786	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.1305	0.4682
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0069	0.2786	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0149	0.0536
Onchocerca volvulus		0.0069	0.2786	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.2786	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0069	0.2786	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.2786	1
Echinococcus multilocularis	orexin receptor type 2	0.0069	0.2786	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	g-protein coupled receptor	0.0069	0.2786	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Echinococcus granulosus	g protein coupled receptor	0.0069	0.2786	1
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0149	0.0536
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.2786	1
Brugia malayi	larval opioid receptor	0.0069	0.2786	1
Brugia malayi	AKH receptor	0.0069	0.2786	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.2786	1
Schistosoma mansoni	hypothetical protein	0.0069	0.2786	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	biogenic amine receptor	0.0069	0.2786	1
Echinococcus multilocularis	serotonin receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0069	0.2786	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.1305	0.4682
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0069	0.2786	1
Echinococcus granulosus	somatostatin receptor	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Schistosoma mansoni	amine GPCR	0.0069	0.2786	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.2786	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0069	0.2786	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0069	0.2786	1
Echinococcus multilocularis	allatostatin A receptor	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0069	0.2786	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0069	0.2786	1
Schistosoma mansoni	histamine h1 receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.2786	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0069	0.2786	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.2786	1
Schistosoma mansoni	amine GPCR	0.0069	0.2786	1
Brugia malayi	sulfakinin receptor protein	0.0069	0.2786	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Schistosoma mansoni	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0069	0.2786	1
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.2786	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.2786	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.2786	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0069	0.2786	1
Schistosoma mansoni	opsin-like receptor	0.0069	0.2786	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.2786	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.2786	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.2786	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0069	0.2786	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.2786	1
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.2786	1
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	g-protein coupled receptor	0.0069	0.2786	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Onchocerca volvulus		0.0069	0.2786	0.5
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0149	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	TYRA-2 protein	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.2786	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.2786	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0069	0.2786	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Schistosoma mansoni	neuropeptide receptor	0.0069	0.2786	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0069	0.2786	1
Schistosoma mansoni	amine GPCR	0.0069	0.2786	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.2786	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0149	0.0536
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.2786	1
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0069	0.2786	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0069	0.2786	1
Brugia malayi	putative neuropeptide receptor	0.0069	0.2786	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0069	0.2786	1
Brugia malayi	Dopamine receptor	0.0069	0.2786	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.2786	1
Schistosoma mansoni	amine GPCR	0.0069	0.2786	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0069	0.2786	1
Echinococcus multilocularis	neuropeptide receptor	0.0069	0.2786	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0069	0.2786	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	RE15519p	0.0069	0.2786	1
Brugia malayi	neuropeptide F receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Brugia malayi	hypothetical protein	0.0069	0.2786	1
Echinococcus granulosus	serotonin receptor	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	sex peptide receptor	0.0069	0.2786	1
Onchocerca volvulus		0.0069	0.2786	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0069	0.2786	1
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.2786	1
Echinococcus granulosus	hypothetical protein	0.0069	0.2786	1
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0149	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1
Brugia malayi	Dopamine receptor protein 1	0.0069	0.2786	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0069	0.2786	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2786	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 15 uM	Inhibition of demethylase activity of PCA-1 (unknown origin) using 3-methyl cytosine oligo DNA as substrate after 1 hr by RT-PCR analysis	ChEMBL.	24461353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3145432

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1851225