Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | prostaglandin-E synthase | 0.1136 | 0.5 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.1136 | 0.5 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1136 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1136 | 0.5 | 0.5 | |
Trypanosoma brucei | Prostaglandin E synthase | 0.1136 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1136 | 0.5 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.1136 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 55.8 uM | Antiparasitic activity against Trypanosoma cruzi strain CL Brener epimastigotes assessed as growth inhibition after 72 hrs by neubauer chamber analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.