Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | adenylyl cyclase 3 | 0.0541 | 0.2425 | 0.247 |
Loa Loa (eye worm) | hypothetical protein | 0.0541 | 0.2425 | 0.247 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0541 | 0.2425 | 1 |
Onchocerca volvulus | 0.0541 | 0.2425 | 0.2425 | |
Brugia malayi | Adenylyl cyclase protein | 0.0541 | 0.2425 | 1 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0541 | 0.2425 | 0.2425 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0234 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1475 | 0.9818 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0234 | 0 | 0.5 |
Onchocerca volvulus | 0.0518 | 0.2243 | 0.2243 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0234 | 0 | 0.5 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0541 | 0.2425 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 2.85 % | Inhibition of human recombinant PTP1B using phosphopeptide as substrate at 10 uM after 30 mins by malachite green assay relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.