Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.0519 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.1922 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0016 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.0519 | 1 |
Leishmania major | serine-threonine protein kinase-like protein | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.1922 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.1922 | 0.9996 | 0.9995 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.1922 | 0.9996 | 0.9995 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.1466 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.1466 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1922 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1922 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.0519 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 230 nM | Modulation of gamma-secretase (unknown origin) assessed as inhibition of amyloid beta 42 production | ChEMBL. | No reference |
Inhibition (binding) | = 31 % | Modulation of gamma-secretase (unknown origin) assessed as inhibition of amyloid beta 40 production at 20 uM relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.