Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 25B | Starlite/ChEMBL | No references |
Homo sapiens | cell division cycle 25C | Starlite/ChEMBL | No references |
Homo sapiens | cell division cycle 25A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0205 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 1 | 1 |
Onchocerca volvulus | 0.0205 | 1 | 0.5 | |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0205 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0205 | 1 | 0.5 |
Trichomonas vaginalis | cdc25c, putative | 0.0205 | 1 | 0.5 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0205 | 1 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0205 | 1 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0205 | 1 | 0.5 |
Onchocerca volvulus | 0.0205 | 1 | 0.5 | |
Onchocerca volvulus | 0.0205 | 1 | 0.5 | |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0205 | 1 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0205 | 1 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0205 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 1 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0205 | 1 | 0.5 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0205 | 1 | 0.5 |
Onchocerca volvulus | 0.0205 | 1 | 0.5 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0205 | 1 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0205 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0205 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2 uM | Inhibition of Cdc25B (unknown origin) phosphatase activity assessed as fluorescence by BMG plate reader in the presence of 0.005% Tween-20 | ChEMBL. | No reference |
IC50 (binding) | = 6.9 uM | Inhibition of Cdc25A (unknown origin) phosphatase activity assessed as fluorescence by BMG plate reader in the presence of 0.005% Tween-20 | ChEMBL. | No reference |
IC50 (binding) | = 8.6 uM | Inhibition of Cdc25C (unknown origin) phosphatase activity assessed as fluorescence by BMG plate reader in the presence of 0.005% Tween-20 | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibition of human His-tagged VHR phosphatase activity assessed as fluorescence by BMG plate reader in the presence of 0.005% Tween-20 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.