Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | unspecified product | 0.2691 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Loa Loa (eye worm) | casein kinase II | 0.0428 | 0.1497 | 0.1396 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2691 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trypanosoma brucei | Casein kinase II | 0.2691 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.008 | 0.008 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.2691 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.0171 | 0.0091 |
Loa Loa (eye worm) | Csnk2b protein | 0.1466 | 0.5397 | 0.5342 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Giardia lamblia | Kinase, CMGC CK2 | 0.2691 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.2691 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1466 | 0.5397 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0171 | 0.0054 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2691 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.0118 | 0.0118 |
Brugia malayi | casein kinase II, putaitve | 0.0428 | 0.1497 | 0.1497 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2691 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.0096 | 0.0096 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.2691 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.2691 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.2691 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2691 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.0171 | 0.0091 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2691 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.2691 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.2691 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.2691 | 1 | 1 |
Schistosoma mansoni | casein kinase II beta subunit | 0.1466 | 0.5397 | 0.5397 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2691 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Leishmania major | casein kinase II, putative | 0.2691 | 1 | 1 |
Brugia malayi | Csnk2b protein | 0.1466 | 0.5397 | 0.5397 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.1466 | 0.5397 | 0.5359 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.2691 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.1466 | 0.5397 | 0.5359 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2691 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.1466 | 0.5397 | 0.4586 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.0149 | 0.0149 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.1466 | 0.5397 | 0.5 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.2691 | 1 | 1 |
Giardia lamblia | Casein kinase II beta chain | 0.1466 | 0.5397 | 0.4586 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.1466 | 0.5397 | 0.4586 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | = 38 % | Drug metabolism in human liver microsomes at 5 uM after 15 mins | ChEMBL. | No reference |
EC50 (functional) | = 5.7 | Positive allosteric modulation of human mGluR2 expressed in CHO cells assessed as incorporation of [35S]GTPgammaS after 30 mins by scintillation counting analysis | ChEMBL. | No reference |
Emax (functional) | = 80 % | Positive allosteric modulation of human mGluR2 expressed in CHO cells assessed as incorporation of [35S]GTPgammaS at 0.3 nM to 50 uM after 30 mins by scintillation counting analysis relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.