Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 1 | 1 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0112 | 1 | 0.5 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0112 | 1 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 1 | 1 |
Toxoplasma gondii | melibiase subfamily protein | 0.0112 | 1 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0 | 0.5 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0074 | 0 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0112 | 1 | 1 |
Brugia malayi | Melibiase family protein | 0.0074 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Antiproliferative activity against human MCF7 cells after 72 hrs | ChEMBL. | 21887403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.