Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Entamoeba histolytica | cyclin C, putative | 0.0232 | 0.4042 | 1 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0229 | 0.3956 | 0.6962 |
Echinococcus multilocularis | cyclin | 0.0229 | 0.3956 | 0.6962 |
Loa Loa (eye worm) | CMGC/CDK/CDK8 protein kinase | 0.0295 | 0.5682 | 0.5682 |
Echinococcus granulosus | cyclin dependent kinase 19 | 0.0295 | 0.5682 | 1 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.0461 | 1 | 1 |
Loa Loa (eye worm) | gastrulation defective protein 1 | 0.0294 | 0.5655 | 0.5655 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 19 | 0.0295 | 0.5682 | 1 |
Loa Loa (eye worm) | cyclin C | 0.0461 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0229 | 0.3956 | 0.3956 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0295 | 0.5682 | 0.5682 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0229 | 0.3956 | 0.3956 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0 | 0.5 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0229 | 0.3956 | 0.6962 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0 | 0.5 |
Echinococcus granulosus | cyclin | 0.0229 | 0.3956 | 0.6962 |
Brugia malayi | Protein kinase domain containing protein | 0.0295 | 0.5682 | 0.5682 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Inhibitory activity against mixture of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) from nuclear extraction of K562 erythroleukemia cells. | ChEMBL. | 12951120 |
IC50 (binding) | > 1000 nM | Inhibitory activity against mixture of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) from nuclear extraction of K562 erythroleukemia cells. | ChEMBL. | 12951120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.