Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.8068 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0052 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.377 | 0.245 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.3536 |
Chlamydia trachomatis | glutamine binding protein | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0106 | 0.4666 | 0.1439 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA in presence of [3H]- CPP; NT means not tested | ChEMBL. | No reference |
IC50 (binding) | 0 uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA in presence of [3H]- CPP; NT means not tested | ChEMBL. | No reference |
IC50 (binding) | = 77 uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA receptor in presence of [3H]- Gly | ChEMBL. | No reference |
IC50 (binding) | = 77 uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA receptor in presence of [3H]- Gly | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Compound was evaluated for its binding affinity towards Ionotropic glutamate receptor AMPA in presence of [3H]- AMPA | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Compound was evaluated for its binding affinity towards Ionotropic glutamate receptor AMPA in presence of [3H]- AMPA | ChEMBL. | No reference |
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-AMPA from Ionotropic glutamate receptor AMPA. | ChEMBL. | 1382133 |
Ki (binding) | > 10 uM | Displacement of [3H]-glycine from glycine site on the NMDA receptor. | ChEMBL. | 1382133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.