Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.8833 | 0.8833 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.5582 | 0.5582 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0124 | 0.0632 | 0.0632 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0124 | 0.0632 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0423 | 0.9687 | 1 |
Brugia malayi | diacylglycerol acyltransferase | 0.0124 | 0.0632 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0124 | 0.0632 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0124 | 0.0632 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0124 | 0.0632 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0277 | 0.5269 | 1 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0124 | 0.0632 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 333 uM | Inhibition of the 3'-processing activity of HIV-1 integrase | ChEMBL. | 10464020 |
IC50 (binding) | > 333 uM | Inhibition of the 3'-end joining activity of HIV-1 integrase | ChEMBL. | 10464020 |
IC50 (binding) | > 333 uM | Inhibition of the 3'-processing activity of HIV-1 integrase | ChEMBL. | 10464020 |
IC50 (binding) | > 333 uM | Inhibition of the 3'-end joining activity of HIV-1 integrase | ChEMBL. | 10464020 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.