Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | References | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Biotin--acetyl-CoA-carboxylase ligase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.021 | 0 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.021 | 0 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.021 | 0 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.021 | 0 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.021 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.021 | 0 | 0.5 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0448 | 1 | 0.5 |
Chlamydia trachomatis | biotin synthetase | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.021 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0429 | 0.9183 | 0.5 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.021 | 0 | 0.5 |
Schistosoma mansoni | biotin-protein ligase | 0.021 | 0 | 0.5 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.021 | 0 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.021 | 0 | 0.5 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 14.5 degrees C | Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli assessed as change in melting temperature measured across 10 to 85 degC with 1 min incubation per 0.5 degC increase by differential scanning fluorimetric analysis | ChEMBL. | 26299766 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay | ChEMBL. | 26299766 |
Kd (binding) | = 0.865 nM | Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysis | ChEMBL. | 26299766 |
MIC (functional) | = 0.1 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis 37892293 after 16 to 20 hrs by two-fold microdilution broth method | ChEMBL. | 25699152 |
MIC99 (functional) | = 0.16 uM | Antibacterial activity against Mycobacterium tuberculosis XDR1 measured at 7 to 14 days by broth microdilution method | ChEMBL. | 26299766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.