Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0218 | 0.3835 | 0.3835 |
Entamoeba histolytica | protein kinase, putative | 0.0218 | 0.3835 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1741 | 0.5 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0111 | 0.1061 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1741 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0138 | 0.1741 | 0.1741 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0218 | 0.3835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0349 | 0.0909 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 0.1078 | 0.1078 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0138 | 0.1741 | 0.1741 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0138 | 0.1741 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0138 | 0.1741 | 0.454 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0138 | 0.1741 | 0.1741 |
Loa Loa (eye worm) | IRE protein kinase | 0.0218 | 0.3835 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0456 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0138 | 0.1741 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0111 | 0.1061 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1741 | 0.5 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0456 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.007 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0218 | 0.3835 | 0.3835 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0218 | 0.3835 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.29 uM | Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 21711053 |
IC50 (binding) | = 15.9 uM | Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 21711053 |
IC50 (binding) | > 100 uM | Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | ChEMBL. | 21711053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.