Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ribonuclease 2-5A family protein | 0.0328 | 0.4427 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0053 | 0.0573 | 0.7098 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | fibroinase | 0.0018 | 0.0082 | 0.0184 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.2035 | 0.4598 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0337 | 0.0761 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.0775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Echinococcus granulosus | cathepsin l1 | 0.0018 | 0.0082 | 0.0082 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0067 | 0.0152 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.0082 | 0.0184 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0082 | 0.0184 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0067 | 0.0067 |
Toxoplasma gondii | cathepsin CPL | 0.0018 | 0.0082 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0018 | 0.0082 | 0.0184 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0328 | 0.4427 | 0.4427 |
Onchocerca volvulus | 0.0018 | 0.0082 | 1 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0569 | 0.1286 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2035 | 0.4598 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0727 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0082 | 0.0014 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.0082 | 1 | |
Onchocerca volvulus | 0.0018 | 0.0082 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.0082 | 0.0184 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0328 | 0.4427 | 0.4389 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0082 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0337 | 0.0337 |
Onchocerca volvulus | 0.0018 | 0.0082 | 1 | |
Onchocerca volvulus | 0.0018 | 0.0082 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0167 | 0.2175 | 1 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.0082 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0018 | 0.0082 | 0.0184 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0018 | 0.0082 | 0.0082 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0067 | 0.0152 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0018 | 0.0082 | 0.0082 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0082 | 0.0184 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.2035 | 0.2035 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0082 | 0.0184 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0082 | 0.0014 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0082 | 0.0184 |
Entamoeba histolytica | protein kinase, putative | 0.0328 | 0.4427 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0082 | 0.0014 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0569 | 0.1286 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0082 | 0.0082 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.0775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Entamoeba histolytica | cysteine protease, putative | 0.0018 | 0.0082 | 0.0184 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0.0082 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0775 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0775 | 1 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.0082 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.0082 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0082 | 0.0184 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0067 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0067 | 0.0152 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0082 | 0.0014 |
Loa Loa (eye worm) | cysteine protease | 0.0018 | 0.0082 | 0.0184 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0082 | 0.0184 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0569 | 0.1286 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0168 | 0.2189 | 0.2189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2035 | 0.4598 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0018 | 0.0082 | 0.0184 |
Onchocerca volvulus | 0.0018 | 0.0082 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0067 | 0.0775 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0167 | 0.2175 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0067 | 0.0067 |
Entamoeba histolytica | protein kinase, putative | 0.0328 | 0.4427 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.0693 | 0.8824 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0067 | 0.0067 |
Leishmania major | cathepsin L-like protease | 0.0067 | 0.0775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.0082 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0337 | 0.0761 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0082 | 0.0014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0067 | 0.0775 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.2035 | 0.1981 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Onchocerca volvulus | Cathepsin F homolog | 0.0018 | 0.0082 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0.0082 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0018 | 0.0082 | 0.0184 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.2035 | 0.1981 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0.0082 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0775 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0569 | 0.1286 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0082 | 0.0082 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0082 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0067 | 0.0067 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.0082 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Loa Loa (eye worm) | IRE protein kinase | 0.0328 | 0.4427 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0082 | 0.0375 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0067 | 0.0067 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0727 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.