Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ribonucleotide reductase 2 | 0.0146 | 0.031 | 0.031 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.2352 | 0.8678 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.27 | 1 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0146 | 0.031 | 0.0149 |
Brugia malayi | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0183 | 0.045 | 0.045 |
Brugia malayi | Probable DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1249 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0353 | 0.1096 | 0.0974 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.27 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0421 | 0.1353 | 0.1353 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0956 | 0.3381 | 0.3169 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0465 | 0.152 | 0.1249 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0216 | 0.0575 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Echinococcus multilocularis | RUN | 0.0262 | 0.075 | 0.075 |
Onchocerca volvulus | 0.0113 | 0.0183 | 0.2441 | |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0348 | 0.1077 | 0.1052 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0254 | 0.0719 | 0.0422 |
Schistosoma mansoni | lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.27 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3764 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0216 | 0.0575 | 0.0575 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0956 | 0.3381 | 0.3169 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0348 | 0.1077 | 0.1052 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.031 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0124 | 0.0124 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.27 | 1 | 1 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Loa Loa (eye worm) | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | loxhd1 | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.157 | 0.5711 | 0.5711 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0353 | 0.1096 | 0.0811 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3293 |
Echinococcus granulosus | RUN | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.367 |
Schistosoma mansoni | lipoxygenase | 0.1097 | 0.3918 | 0.3918 |
Loa Loa (eye worm) | doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0465 | 0.152 | 0.1446 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0216 | 0.0575 | 0.0575 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.3106 | 0.3106 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0146 | 0.031 | 0.0178 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.0452 | 0.0452 |
Schistosoma mansoni | serine-type protease inhibitor | 0.0442 | 0.1432 | 0.1432 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0146 | 0.031 | 0.0181 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0262 | 0.075 | 0.0454 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1407 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0146 | 0.031 | 0.0149 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Schistosoma mansoni | polycystin 1-related | 0.0262 | 0.075 | 0.075 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.002 | 0.002 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.0906 | 0.0906 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0956 | 0.3381 | 0.3764 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0134 | 0.0134 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Chlamydia trachomatis | transcriptional repressor NrdR | 0.0348 | 0.1077 | 0.0958 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0465 | 0.152 | 0.1249 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0216 | 0.0575 | 0.766 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.018 | 0.0439 | 0.0309 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0124 | 0.0124 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Echinococcus multilocularis | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0131 | 0.0131 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0124 | 0.0124 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0465 | 0.152 | 0.1574 |
Brugia malayi | hypothetical protein | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Schistosoma mansoni | DNA topoisomerase II | 0.0216 | 0.0575 | 0.0575 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.018 | 0.0439 | 0.0133 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.002 | 0.002 |
Mycobacterium leprae | conserved hypothetical protein | 0.0348 | 0.1077 | 0.1052 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.27 | 1 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0183 | 0.045 | 0.045 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.2352 | 0.8678 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0353 | 0.1096 | 0.0811 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.0906 | 0.0906 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0262 | 0.075 | 0.075 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.018 | 0.0439 | 0.0309 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0124 | 0.0124 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0216 | 0.0575 | 0.0273 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0721 | 0.2492 | 0.2252 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0007 | 0.0007 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0456 | 0.1483 | 0.153 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0216 | 0.0575 | 0.0575 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.2352 | 0.8678 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0137 | 0.0276 | 0.0109 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0146 | 0.031 | 0.031 |
Leishmania major | DNA topoisomerase ii | 0.018 | 0.0439 | 0.0133 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.27 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0113 | 0.0183 | 0.0183 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0049 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0956 | 0.3381 | 0.3169 |
Brugia malayi | Doublecortin family protein | 0.0262 | 0.075 | 0.075 |
Brugia malayi | hypothetical protein | 0.007 | 0.002 | 0.002 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0216 | 0.0575 | 0.0575 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0328 | 0.0999 | 0.088 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0465 | 0.152 | 0.1574 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0063 | 0.0063 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0432 | 0.0432 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0146 | 0.031 | 0.031 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.002 | 0.002 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0358 | 0.0227 |
Onchocerca volvulus | 0.0262 | 0.075 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.002 | 0.002 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0262 | 0.075 | 0.0454 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0184 | 0.0452 | 0.0452 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0146 | 0.031 | 0.0178 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0956 | 0.3381 | 0.3169 |
Giardia lamblia | DNA topoisomerase II | 0.02 | 0.0515 | 0.5 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.2352 | 0.8678 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0358 | 0.0049 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0845 | 0.2963 | 0.3272 |
Schistosoma mansoni | rab6-interacting | 0.0262 | 0.075 | 0.075 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.27 | 1 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0216 | 0.0575 | 0.766 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0216 | 0.0575 | 0.0273 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0607 | 0.0607 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 10.1 % |
Compound (50 mM) was tested in vitro for inhibitory potency against Fas-associated phosphatase- 1 binding from HFAP-10cDNA subcloned into the bluescript vector pSK-II(Stratagene) |
ChEMBL. | 10464015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.