Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | jun proto-oncogene | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | bZIP transcription factor family protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus multilocularis | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Echinococcus granulosus | jun protein | Get druggable targets OG5_131442 | All targets in OG5_131442 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.787 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3502 | 0.5 |
Brugia malayi | hypothetical protein | 0.008 | 0.7559 | 0.7559 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3502 | 0.3502 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3502 | 0.445 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3502 | 0.3502 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3502 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 1 | 1 |
Onchocerca volvulus | 0.008 | 0.7559 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.9688 | 1 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.787 | 1 |
Echinococcus multilocularis | jun protein | 0.0101 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3502 | 0.3502 |
Echinococcus granulosus | jun protein | 0.0101 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3502 | 0.445 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3502 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3502 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2113 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.3378 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.3758 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.