Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0372 | 0.0372 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0191 | 0.2198 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.0591 | 0.0591 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.3412 | 0.3412 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Entamoeba histolytica | protein kinase , putative | 0.0466 | 0.6976 | 0.6976 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0372 | 0.0372 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Trypanosoma brucei | aurora B kinase | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0169 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0722 | 0.0722 |
Echinococcus granulosus | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0372 | 0.0372 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0169 | 0.0168 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0191 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.0591 | 0.0591 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Onchocerca volvulus | 0.0291 | 0.4298 | 0.4138 | |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0483 | 0.0483 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0664 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0191 | 0.0191 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Onchocerca volvulus | 0.0033 | 0.0372 | 0.0103 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0111 | 0.156 | 0.156 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0722 | 0.0722 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0755 | 0.0755 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0372 | 0.0372 |
Echinococcus multilocularis | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.0591 | 0.0591 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0451 | 0.045 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.156 | 0.156 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0722 | 0.0722 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0272 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Echinococcus multilocularis | geminin | 0.0194 | 0.2818 | 0.2818 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.3902 | 0.3902 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0272 | 0.0122 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0664 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Onchocerca volvulus | 0.0265 | 0.3902 | 0.3732 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Plasmodium vivax | RNA helicase-1, putative | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0113 | 0.1586 | 0.1586 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0664 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0111 | 0.156 | 0.156 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0191 | 0.004 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0169 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0191 | 0.0191 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0722 | 0.0722 |
Toxoplasma gondii | aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0272 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0354 | 0.0353 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0272 | 0.0122 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Brugia malayi | serine/threonine kinase 12 | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Giardia lamblia | Aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0483 | 0.0483 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0272 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0664 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0169 | 0.0168 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0664 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0194 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0372 | 0.0372 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.3412 | 0.3412 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Schistosoma mansoni | protein kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0483 | 0.0483 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.