Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0376 | 0.6412 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0124 | 0.1934 | 0.1815 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0579 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0376 | 0.6412 | 1 |
Brugia malayi | thymidylate synthase | 0.0124 | 0.1934 | 0.1934 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0.0781 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0579 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0145 | 0.0145 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0579 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0376 | 0.6412 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0579 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0376 | 0.6412 | 1 |
Onchocerca volvulus | 0.0124 | 0.1934 | 0.5 | |
Brugia malayi | Dihydrofolate reductase | 0.0579 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.0547 | 0.0547 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.029 | 0.029 |
Schistosoma mansoni | dihydrofolate reductase | 0.0579 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0059 | 0.0781 | 0.1014 |
Echinococcus granulosus | dihydrofolate reductase | 0.0579 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0376 | 0.6412 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.0547 | 0.0547 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0579 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0046 | 0.0547 | 0.0407 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0579 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0059 | 0.0781 | 0.0781 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0124 | 0.1934 | 0.1693 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0376 | 0.6412 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0124 | 0.1934 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0547 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.029 | 0.0147 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4467 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.