Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0664 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0033 | 0.0372 | 0.0103 | |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0722 | 0.0722 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0169 | 0.0168 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0191 | 0.004 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0483 | 0.0483 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.156 | 0.156 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0191 | 0.0191 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.0591 | 0.0591 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0191 | 0.0191 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0111 | 0.156 | 0.156 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0272 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0135 | 0.0135 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0664 | 1 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0722 | 0.0722 |
Plasmodium vivax | RNA helicase-1, putative | 0.0664 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0372 | 0.0372 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0191 | 0.0191 |
Onchocerca volvulus | 0.0265 | 0.3902 | 0.3732 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0272 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0372 | 0.0372 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0372 | 0.0372 |
Giardia lamblia | Aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0664 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0113 | 0.1586 | 0.1586 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.3412 | 0.3412 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.0591 | 0.0591 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0664 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0354 | 0.0353 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0694 | 0.0694 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0169 | 0.0168 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Schistosoma mansoni | protein kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.3412 | 0.3412 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Toxoplasma gondii | aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | geminin | 0.0194 | 0.2818 | 0.2818 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0191 | 0.2198 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0191 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0272 | 0.0122 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0169 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0372 | 0.0372 |
Echinococcus granulosus | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0483 | 0.0483 |
Echinococcus multilocularis | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0272 | 0.0122 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.0591 | 0.0591 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0722 | 0.0722 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0111 | 0.156 | 0.156 |
Leishmania major | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.0591 | 0.0591 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0664 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0372 | 0.0372 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0291 | 0.4298 | 0.4138 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.3902 | 0.3902 |
Echinococcus multilocularis | geminin | 0.0194 | 0.2818 | 0.2818 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0169 | 0.0017 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0272 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0451 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0372 | 0.0372 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.