Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | serine/threonine kinase 12 | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0483 | 0.0483 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0354 | 0.0353 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0272 | 0.0122 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0191 | 0.0191 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0722 | 0.0722 |
Toxoplasma gondii | aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0272 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0169 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.0591 | 0.0591 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0483 | 0.0483 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Schistosoma mansoni | protein kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.3412 | 0.3412 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0194 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0664 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0664 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0169 | 0.0168 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0272 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.156 | 0.156 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0722 | 0.0722 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0451 | 0.045 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0466 | 0.6976 | 0.6976 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.0591 | 0.0591 |
Echinococcus multilocularis | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0755 | 0.0755 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0191 | 0.004 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0111 | 0.156 | 0.156 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Plasmodium vivax | RNA helicase-1, putative | 0.0664 | 1 | 1 |
Onchocerca volvulus | 0.0265 | 0.3902 | 0.3732 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0664 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0113 | 0.1586 | 0.1586 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0664 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0272 | 0.0122 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.3902 | 0.3902 |
Echinococcus multilocularis | geminin | 0.0194 | 0.2818 | 0.2818 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0483 | 0.0483 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0664 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0191 | 0.0191 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.0591 | 0.0591 |
Onchocerca volvulus | 0.0291 | 0.4298 | 0.4138 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0169 | 0.0168 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0191 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0694 | 0.0694 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0111 | 0.156 | 0.156 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0033 | 0.0372 | 0.0103 | |
Trypanosoma cruzi | aurora B kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Entamoeba histolytica | protein kinase , putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.3412 | 0.3412 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0372 | 0.0372 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0191 | 0.2198 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0372 | 0.0372 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0169 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0722 | 0.0722 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Trypanosoma brucei | aurora B kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.