Detailed information for compound 186956

Basic information

Technical information
  • TDR Targets ID: 186956
  • Name: 4-tert-butyl-N-[5-(furan-2-yl)-6-[2-(5-methyl sulfanylpyrimidin-2-yl)oxyethoxy]pyrimidin-4- yl]benzenesulfonamide
  • MW: 541.642 | Formula: C25H27N5O5S2
  • H donors: 1 H acceptors: 6 LogP: 4.56 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CSc1cnc(nc1)OCCOc1ncnc(c1c1ccco1)NS(=O)(=O)c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C25H27N5O5S2/c1-25(2,3)17-7-9-19(10-8-17)37(31,32)30-22-21(20-6-5-11-33-20)23(29-16-28-22)34-12-13-35-24-26-14-18(36-4)15-27-24/h5-11,14-16H,12-13H2,1-4H3,(H,28,29,30)
  • InChiKey: BLWJVNAITNJJCT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-tert-butyl-N-[5-(2-furyl)-6-[2-(5-methylsulfanylpyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]benzenesulfonamide
  • 4-tert-butyl-N-[5-(2-furyl)-6-[2-[[5-(methylthio)-2-pyrimidinyl]oxy]ethoxy]-4-pyrimidinyl]benzenesulfonamide
  • 4-tert-butyl-N-[5-(2-furyl)-6-[2-[5-(methylthio)pyrimidin-2-yl]oxyethoxy]pyrimidin-4-yl]benzenesulfonamide
  • 4-tert-butyl-N-[5-furan-2-yl-6-[2-(5-methylsulfanylpyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Endothelin receptor ET-A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0136 0.0307
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0026 0.0059
Echinococcus multilocularis somatostatin receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0177 0.0228
Schistosoma mansoni histamine h1 receptor 0.0026 0.0177 0.04
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0026 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0177 0.04
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Onchocerca volvulus 0.0026 0.0177 0.0843
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.5
Loa Loa (eye worm) hypothetical protein 0.0282 0.2972 0.3833
Brugia malayi putative neuropeptide receptor 0.0026 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0177 0.0228
Schistosoma mansoni nAChR subunit 0.0012 0.0026 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0557 0.5
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0287 0.065
Onchocerca volvulus 0.0012 0.0026 0.0125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0026 0.0034
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0026 0.0034
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0177 0.04
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0026 0.0059
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0177 0.0177
Echinococcus multilocularis nAChR subunit 0.0012 0.0026 0.0059
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0177 0.04
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0177 0.04
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.1577 0.1577
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0177 0.04
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Onchocerca volvulus 0.0026 0.0177 0.0843
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0177 0.04
Schistosoma mansoni opsin-like receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.1577 0.2034
Schistosoma mansoni hypothetical protein 0.0026 0.0177 0.04
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0026 0.0026
Schistosoma mansoni nAChR subunit 0.0012 0.0026 0.0059
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0415 0.442 1
Brugia malayi neuropeptide F receptor 0.0026 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0961
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0665 0.0857
Schistosoma mansoni hypothetical protein 0.0036 0.0286 0.0647
Loa Loa (eye worm) hypothetical protein 0.0105 0.1044 0.1346
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0177 0.04
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0177 0.04
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.005 0.0436 0.0562
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0026 0.0059
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0177 0.04
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0596 0.1347
Echinococcus granulosus nAChR subunit 0.0012 0.0026 0.0059
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Onchocerca volvulus 0.0012 0.0026 0.0125
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0177 0.04
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.1063 0.1063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0026 0.0059
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0177 0.04
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0177 0.04
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0026 0.0059
Onchocerca volvulus 0.0012 0.0026 0.0125
Onchocerca volvulus 0.0026 0.0177 0.0843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0401 0.0906
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0177 0.04
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0177 0.04
Trypanosoma cruzi C-8 sterol isomerase, putative 0.072 0.7754 1
Echinococcus granulosus orexin receptor type 2 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0177 0.04
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0956 0.2163
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0026 0.0026
Brugia malayi Dopamine receptor protein 1 0.0026 0.0177 0.0177
Schistosoma mansoni biogenic amine receptor 0.0026 0.0177 0.04
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0177 0.04
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0026 0.0026
Brugia malayi larval opioid receptor 0.0026 0.0177 0.0177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0401 0.0517
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0557 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.5
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0026 0.0059
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0177 0.04
Onchocerca volvulus 0.0026 0.0177 0.0843
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0956 0.2163
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0177 0.04
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0026 0.0034
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0177 0.04
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0026 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0177 0.04
Schistosoma mansoni hypothetical protein 0.0026 0.0177 0.04
Brugia malayi Dopamine receptor protein 2 0.0026 0.0177 0.0177
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0177 0.04
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0026 0.0026
Brugia malayi G-protein coupled receptor 0.0026 0.0177 0.0177
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.1063 0.1063
Onchocerca volvulus 0.0012 0.0026 0.0125
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0177 0.04
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0177 0.04
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0026 0.0026
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.0026 0.0059
Echinococcus granulosus fmrfamide receptor 0.0026 0.0177 0.04
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0177 0.04
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0177 0.04
Onchocerca volvulus 0.0107 0.1063 0.5072
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0177 0.04
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0026 0.0059
Schistosoma mansoni myosin xvIII 0.0026 0.0177 0.04
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0026 0.0059
Echinococcus granulosus neuropeptide receptor 0.0026 0.0177 0.04
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0026 0.0026
Schistosoma mansoni nAChR subunit 0.0012 0.0026 0.0059
Onchocerca volvulus 0.0026 0.0177 0.0843
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0177 0.04
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0177 0.0177
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0425 0.0425
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0177 0.0843
Onchocerca volvulus 0.0026 0.0177 0.0843
Schistosoma mansoni amine GPCR 0.0026 0.0177 0.04
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0026 0.0026
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Onchocerca volvulus 0.0026 0.0177 0.0843
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0026 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0177 0.04
Echinococcus granulosus g protein coupled receptor 0.0026 0.0177 0.04
Schistosoma mansoni biogenic amine (5HT) receptor 0.0264 0.2777 0.6282
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0177 0.04
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0665 0.1504
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0177 0.04
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0177 0.04
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0665 0.1504
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0177 0.0228
Brugia malayi G protein-coupled receptor 0.0026 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus granulosus sex peptide receptor 0.0026 0.0177 0.04
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0026 0.0059
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0177 0.04
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0425 0.0961
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0177 0.04
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0557 0.1261
Loa Loa (eye worm) hypothetical protein 0.0107 0.1063 0.137
Onchocerca volvulus 0.0026 0.0177 0.0843
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Schistosoma mansoni nAChR subunit 0.0012 0.0026 0.0059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.1577 0.1577
Echinococcus granulosus biogenic amine 5HT receptor 0.0264 0.2777 0.6282
Loa Loa (eye worm) hypothetical protein 0.0033 0.0252 0.0325
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0177 0.04
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0177 0.04
Schistosoma mansoni nAChR subunit 0.0012 0.0026 0.0059
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0177 0.04
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0177 0.04
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0286 0.0647
Schistosoma mansoni hypothetical protein 0.0107 0.1063 0.2404
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0961
Loa Loa (eye worm) hypothetical protein 0.0154 0.1577 0.2034
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0177 0.04
Schistosoma mansoni transient receptor potential channel 0.0097 0.0956 0.2163
Brugia malayi AKH receptor 0.0026 0.0177 0.0177
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0026 0.0059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0401 0.0906
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0026 0.0026
Brugia malayi N-terminal motif family protein 0.0202 0.2095 0.2095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Schistosoma mansoni neuropeptide receptor 0.0026 0.0177 0.04
Leishmania major C-8 sterol isomerase-like protein 0.072 0.7754 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0026 0.0059
Brugia malayi ERG2 and Sigma1 receptor like protein 0.072 0.7754 0.7754
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Onchocerca volvulus 0.0026 0.0177 0.0843
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0961
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0036 0.0287 0.0371
Brugia malayi ORL1-like opioid receptor 0.0026 0.0177 0.0177
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0956 0.2163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0425 0.0548
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0177 0.04
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0177 0.04
Loa Loa (eye worm) RNA binding protein 0.0071 0.0665 0.0857
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0026 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0177 0.04
Schistosoma mansoni hypothetical protein 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Schistosoma mansoni opsin-like receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0107 0.1063 0.137
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0177 0.04
Brugia malayi hypothetical protein 0.0036 0.0286 0.0286
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.0049 0.0425 0.0548
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0026 0.0034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0425 0.0961
Loa Loa (eye worm) hypothetical protein 0.0368 0.391 0.5043
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0026 0.0034
Brugia malayi Dopamine receptor 0.0026 0.0177 0.0177
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0202 0.2095 1
Echinococcus multilocularis sex peptide receptor 0.0026 0.0177 0.04
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0436 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0177 0.04
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.092 0.2082
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0177 0.04
Schistosoma mansoni biogenic amine receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0026 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0401 0.0906
Brugia malayi Cation transporter family protein 0.0012 0.0026 0.0026
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0557 0.1261
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0026 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0177 0.0177
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0177 0.0177
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0177 0.04
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0136 0.0307
Echinococcus granulosus g protein coupled receptor 0.0026 0.0177 0.04
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0287 0.0287
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0177 0.04
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0557 0.1261
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Brugia malayi Cation transporter family protein 0.0012 0.0026 0.0026
Brugia malayi RNA binding protein 0.0071 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0264 0.2777 0.3581
Onchocerca volvulus 0.0026 0.0177 0.0843
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0177 0.04
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0286 0.0647
Onchocerca volvulus 0.0026 0.0177 0.0843
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0177 0.04
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Echinococcus granulosus serotonin receptor 0.0026 0.0177 0.04
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0665 0.1504
Brugia malayi RE15519p 0.0026 0.0177 0.0177
Echinococcus granulosus GPCR family 2 0.0049 0.0425 0.0961
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.092 0.2082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0436 0.7819
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0401 0.0906
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0177 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0107 0.1063 0.2404
Onchocerca volvulus Deterin homolog 0.0107 0.1063 0.5072
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0026 0.0026
Schistosoma mansoni neuropeptide receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0415 0.442 0.57
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0026 0.0059
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0177 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0665 0.1504
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Brugia malayi Serine/threonine-protein kinase SULU 0.0415 0.442 0.442
Onchocerca volvulus 0.0026 0.0177 0.0843
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0177 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0286 0.0647
Brugia malayi Melatonin receptor type 1A 0.0026 0.0177 0.0177
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0177 0.04
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0202 0.2095 0.2702
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Onchocerca volvulus 0.0026 0.0177 0.0843
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0026 0.0026
Schistosoma mansoni transient receptor potential channel 0.0064 0.0596 0.1347
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0665 0.1504
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0177 0.04
Schistosoma mansoni hypothetical protein 0.0022 0.0136 0.0307
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0177 0.04
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0415 0.442 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Brugia malayi hypothetical protein 0.0415 0.442 0.442
Onchocerca volvulus 0.0026 0.0177 0.0843
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0026 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0425 0.0425
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0177 0.04
Schistosoma mansoni biogenic amine receptor 0.0026 0.0177 0.04
Echinococcus granulosus neuropeptide receptor 0.0026 0.0177 0.04
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Schistosoma mansoni neuropeptide receptor 0.0026 0.0177 0.04
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0557 0.1261
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0436 0.5
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Brugia malayi Cation transporter family protein 0.0012 0.0026 0.0026
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0026 0.0059
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0665 0.0665
Brugia malayi neuropeptide F receptor 0.0026 0.0177 0.0177
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0596 0.1347
Echinococcus granulosus hypothetical protein 0.0026 0.0177 0.04
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0177 0.04
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0026 0.0059
Echinococcus multilocularis serotonin receptor 0.0264 0.2777 0.6282
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0177 0.04
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0177 0.04
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0665 0.0857
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0061 0.056 0.0722
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0401 0.0401
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0026 0.0059
Echinococcus granulosus somatostatin receptor 0.0026 0.0177 0.04
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0026 0.0059
Brugia malayi GnHR receptor homolog 0.0026 0.0177 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.0415 0.442 1
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0177 0.04
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.0026 0.0059
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0026 0.0034
Onchocerca volvulus 0.0026 0.0177 0.0843
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0107 0.1063 0.2404
Brugia malayi G-protein coupled receptor 0.0026 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0961
Echinococcus granulosus allatostatin A receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0177 0.04
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0177 0.0228
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0557 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0401 0.0906
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0177 0.04
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0026 0.0026
Brugia malayi hypothetical protein 0.0032 0.0243 0.0243
Schistosoma mansoni amine GPCR 0.0026 0.0177 0.04
Schistosoma mansoni inhibitor of apoptosis protein 0.0107 0.1063 0.2404
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0177 0.04
Schistosoma mansoni adenoreceptor 0.0026 0.0177 0.04
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Schistosoma mansoni nAChR subunit 0.0012 0.0026 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0177 0.0177
Schistosoma mansoni neuropeptide receptor 0.0026 0.0177 0.04
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0596 0.1347
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0177 0.04
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0107 0.1063 0.2404
Brugia malayi sulfakinin receptor protein 0.0026 0.0177 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0665 0.1504
Schistosoma mansoni hypothetical protein 0.0105 0.1044 0.2361
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0177 0.04
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0425 0.0961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0401 0.0906
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0557 0.0166
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0596 0.1347
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0097 0.0956 0.1233
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0557 0.5
Echinococcus multilocularis GPCR, family 2 0.0049 0.0425 0.0961
Echinococcus granulosus g protein coupled receptor 0.0026 0.0177 0.04
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0177 0.0843
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0177 0.0228
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0177 0.0177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0425 0.0961
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Schistosoma mansoni amine GPCR 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0287 0.065
Brugia malayi hypothetical protein 0.0026 0.0177 0.0177
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.1044 0.1044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0177 0.04
Schistosoma mansoni hypothetical protein 0.0026 0.0177 0.04
Onchocerca volvulus 0.0012 0.0026 0.0125
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Schistosoma mansoni opsin-like receptor 0.0026 0.0177 0.04
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0264 0.2777 0.3581
Echinococcus multilocularis inhibitor of apoptosis protein 0.0107 0.1063 0.2404
Echinococcus granulosus tar DNA binding protein 0.0071 0.0665 0.1504
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0401 0.0906
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0026 0.0059
Schistosoma mansoni transient receptor potential channel 0.0064 0.0596 0.1347
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0436 0.5
Loa Loa (eye worm) hypothetical protein 0.072 0.7754 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0557 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Trypanosoma brucei C-8 sterol isomerase, putative 0.072 0.7754 1
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0177 0.04
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0026 0.0059
Brugia malayi Serotonin receptor 0.0026 0.0177 0.0177
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0177 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0177 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0177 0.04
Onchocerca volvulus 0.0012 0.0026 0.0125
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Onchocerca volvulus Putative nachr subunit 0.0012 0.0026 0.0125
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Schistosoma mansoni amine GPCR 0.0026 0.0177 0.04
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0177 0.0177
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0177 0.04
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0177 0.04
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0026 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0177 0.04
Onchocerca volvulus 0.0026 0.0177 0.0843
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0228
Echinococcus multilocularis serotonin receptor 0.0264 0.2777 0.6282
Onchocerca volvulus 0.0026 0.0177 0.0843
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0034
Schistosoma mansoni nAChR subunit 0.0012 0.0026 0.0059
Echinococcus granulosus inhibitor of apoptosis protein 0.0107 0.1063 0.2404
Schistosoma mansoni amine GPCR 0.0026 0.0177 0.04
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0177 0.04
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0177 0.04
Brugia malayi TAR-binding protein 0.0071 0.0665 0.0665
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0026 0.0059
Brugia malayi hypothetical protein 0.005 0.0436 0.0436
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0177 0.0228
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0026 0.0026

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.9 nM In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells ChEMBL. 11585441
IC50 (binding) = 2.9 nM In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells ChEMBL. 11585441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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