Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Disintegrin family protein | 0.0069 | 0.0662 | 0.179 |
Echinococcus granulosus | caspase 2 | 0.0076 | 0.0803 | 0.0803 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0046 | 0.024 | 0.024 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0076 | 0.0803 | 0.082 |
Plasmodium falciparum | plasmepsin I | 0.0078 | 0.0828 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0078 | 0.0828 | 0.0828 |
Onchocerca volvulus | 0.0234 | 0.3696 | 1 | |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0578 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0803 | 0.1926 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.024 | 0.0356 |
Echinococcus multilocularis | caspase 2 | 0.0076 | 0.0803 | 0.0803 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0234 | 0.3696 | 0.3696 |
Brugia malayi | Hemopexin family protein | 0.009 | 0.1061 | 0.287 |
Loa Loa (eye worm) | matrixin family protein | 0.0141 | 0.1997 | 0.5258 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0597 | 0.061 |
Echinococcus granulosus | insulin receptor | 0.0039 | 0.0113 | 0.0113 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0103 | 0.1291 | 0.1318 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0065 | 0.0597 | 0.0597 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0078 | 0.0827 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3696 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0078 | 0.0827 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0039 | 0.0113 | 0.0113 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0234 | 0.3696 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0572 | 0.1282 |
Loa Loa (eye worm) | matrixin family protein | 0.0154 | 0.2231 | 0.5911 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0572 | 0.1282 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0078 | 0.0828 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0039 | 0.0113 | 0.0115 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0078 | 0.0828 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0076 | 0.0803 | 0.0803 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0572 | 0.1547 |
Brugia malayi | Matrixin family protein | 0.0154 | 0.2231 | 0.6035 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0234 | 0.3696 | 0.3696 |
Plasmodium falciparum | plasmepsin VI | 0.0078 | 0.0828 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0064 | 0.0584 | 0.0597 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0064 | 0.0572 | 0.1282 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0232 | 0.3656 | 0.3656 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0234 | 0.3696 | 0.3696 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0069 | 0.0662 | 0.0676 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0121 | 0.1626 | 0.4223 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0121 | 0.1626 | 0.4399 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0078 | 0.0828 | 0.0846 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0067 | 0.0637 | 0.065 |
Onchocerca volvulus | 0.0076 | 0.0803 | 0.0739 | |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0803 | 0.1926 |
Brugia malayi | Cell death protein 3 precursor | 0.0076 | 0.0803 | 0.2172 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0572 | 0.1547 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0597 | 0.061 |
Echinococcus multilocularis | 0.0038 | 0.009 | 0.009 | |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0234 | 0.3696 | 0.3696 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0803 | 0.2172 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0078 | 0.0828 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0046 | 0.024 | 0.024 |
Schistosoma mansoni | tyrosine kinase | 0.0121 | 0.1626 | 0.1661 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0572 | 0.1547 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0078 | 0.0827 | 0.2237 |
Mycobacterium ulcerans | hydrolase | 0.0078 | 0.0827 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0572 | 0.1282 |
Onchocerca volvulus | Matrilysin homolog | 0.0141 | 0.1997 | 0.4561 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0234 | 0.3696 | 0.3775 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0039 | 0.0113 | 0.0113 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0076 | 0.0803 | 0.0803 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0078 | 0.0828 | 0.1996 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0078 | 0.0828 | 0.0828 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0234 | 0.3696 | 0.3775 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0828 | 0.1996 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0803 | 0.082 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0069 | 0.0662 | 0.0662 |
Plasmodium vivax | plasmepsin IV, putative | 0.0078 | 0.0828 | 0.5 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0566 | 0.979 | 1 |
Schistosoma mansoni | hypothetical protein | 0.009 | 0.1061 | 0.1084 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0039 | 0.0113 | 0.0113 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0121 | 0.1626 | 0.1626 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0064 | 0.0572 | 0.0584 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0234 | 0.3696 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0234 | 0.3696 | 0.3775 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3696 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0229 | 0.3606 | 0.3684 |
Plasmodium falciparum | plasmepsin IV | 0.0078 | 0.0828 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0039 | 0.0113 | 0.0304 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0065 | 0.0597 | 0.0597 |
Onchocerca volvulus | Deterin homolog | 0.0234 | 0.3696 | 1 |
Loa Loa (eye worm) | disintegrin family protein | 0.005 | 0.0318 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0827 | 0.1993 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0078 | 0.0828 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0039 | 0.0113 | 0.0115 |
Schistosoma mansoni | tyrosine kinase | 0.0064 | 0.0584 | 0.0597 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0069 | 0.0662 | 0.0662 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0065 | 0.0597 | 0.0597 |
Schistosoma mansoni | tyrosine kinase | 0.0064 | 0.0584 | 0.0597 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0121 | 0.1626 | 0.1626 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0229 | 0.3606 | 0.3684 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0076 | 0.0803 | 0.0739 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0572 | 0.1547 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0232 | 0.3656 | 0.3656 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0141 | 0.1997 | 0.4561 |
Plasmodium falciparum | plasmepsin II | 0.0078 | 0.0828 | 0.5 |
Onchocerca volvulus | 0.009 | 0.1061 | 0.1565 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 77.1937 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.