Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | vesicular acetylcholine transporter | 1.4129 | 0.4425 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0466 | 0.0105 | 0.0238 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.5775 | 0.1784 | 0.1784 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0466 | 0.0105 | 0.0238 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0132 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 1.3343 | 0.4177 | 0.9438 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 1.3343 | 0.4177 | 0.9438 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 1.4129 | 0.4425 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 1.4129 | 0.4425 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 1.4129 | 0.4425 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 1.3343 | 0.4177 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 1.4129 | 0.4425 | 0.4425 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 1.3343 | 0.4177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.682 | 0.2114 | 0.4778 |
Schistosoma mansoni | amine GPCR | 0.0231 | 0.0031 | 0.0031 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 1.4129 | 0.4425 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 1.3343 | 0.4177 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.