Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0191 | 0.0191 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0111 | 0.156 | 0.156 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0372 | 0.0372 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0135 | 0.0135 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Onchocerca volvulus | 0.0033 | 0.0372 | 0.0103 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0372 | 0.0372 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0664 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0483 | 0.0483 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.0591 | 0.0591 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Onchocerca volvulus | 0.0291 | 0.4298 | 0.4138 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0111 | 0.156 | 0.156 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0191 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0169 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0694 | 0.0694 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0135 | 0.0135 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0372 | 0.0372 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0451 | 0.045 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0272 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.0272 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0722 | 0.0722 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0169 | 0.0017 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Trypanosoma brucei | aurora B kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0372 | 0.0372 |
Entamoeba histolytica | protein kinase , putative | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0664 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0048 | 0.0591 | 0.0591 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.3412 | 0.3412 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0191 | 0.2198 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0372 | 0.0372 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0135 | 0.0135 |
Echinococcus granulosus | expressed conserved protein | 0.0104 | 0.1457 | 0.1457 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.4298 | 0.4298 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0191 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.0591 | 0.0591 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0483 | 0.0483 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Schistosoma mansoni | protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.3412 | 0.3412 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | AGC family protein kinase | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0591 | 0.0591 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0194 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0664 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0272 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0169 | 0.0168 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0664 | 1 | 1 |
Giardia lamblia | Aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0191 | 0.0191 |
Brugia malayi | serine/threonine kinase 12 | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0483 | 0.0483 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0135 | 0.0135 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0272 | 0.0122 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0354 | 0.0353 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0664 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0565 | 0.0565 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0272 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0722 | 0.0722 |
Toxoplasma gondii | aurora kinase | 0.0466 | 0.6976 | 0.6976 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0466 | 0.6976 | 0.6976 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0169 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0664 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0191 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0169 | 0.0168 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0466 | 0.6976 | 0.6976 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0466 | 0.6976 | 0.6976 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0664 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0111 | 0.156 | 0.156 |
Plasmodium vivax | RNA helicase-1, putative | 0.0664 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Onchocerca volvulus | 0.0265 | 0.3902 | 0.3732 | |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0664 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0272 | 0.0272 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0664 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0466 | 0.6976 | 0.6976 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0113 | 0.1586 | 0.1586 |
Loa Loa (eye worm) | AUR protein kinase | 0.0466 | 0.6976 | 0.6976 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0664 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0272 | 0.0122 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0272 | 0.0272 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0159 | 0.2288 | 0.2288 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0272 | 0.0272 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.3902 | 0.3902 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.2818 | 0.2818 |
Echinococcus multilocularis | geminin | 0.0194 | 0.2818 | 0.2818 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0191 | 0.0191 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0272 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.156 | 0.156 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0272 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0451 | 0.045 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0466 | 0.6976 | 0.6976 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.0591 | 0.0591 |
Echinococcus multilocularis | aurora kinase A | 0.0466 | 0.6976 | 0.6976 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0135 | 0.0135 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0466 | 0.6976 | 0.6976 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0755 | 0.0755 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0483 | 0.0483 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.