TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.534 | Formula: C28H28N2O2
H donors: 2 H acceptors: 1 LogP: 4.81 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@H]1Nc2ccc(cc2[C@H]2[C@@H]1CCN2Cc1ccccc1OC)C#Cc1ccccc1
InChi: 1S/C28H28N2O2/c1-32-27-10-6-5-9-22(27)18-30-16-15-23-26(19-31)29-25-14-13-21(17-24(25)28(23)30)12-11-20-7-3-2-4-8-20/h2-10,13-14,17,23,26,28-29,31H,15-16,18-19H2,1H3/t23-,26+,28-/m1/s1
InChiKey: MENQJJQMXIRPEC-RXWNPYQGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0061	0.3812	0.5
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	sex peptide receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0086	0.7299	1
Brugia malayi	Isocitrate dehydrogenase	0.0034	0.0008	0.0008
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0086	0.7299	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0061	0.3812	0.3812
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0086	0.7299	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0061	0.3812	0.5223
Echinococcus multilocularis	isocitrate dehydrogenase	0.0034	0.0008	0.001
Loa Loa (eye worm)	neuropeptide F receptor	0.0061	0.3812	0.3812
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0034	0.0008	0.001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0061	0.3812	0.3812
Brugia malayi	G-protein coupled receptor	0.0061	0.3812	0.3812
Echinococcus granulosus	g protein coupled receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	Glycosyl transferase family 8	0.0079	0.633	0.8673
Onchocerca volvulus		0.0061	0.3812	0.5
Onchocerca volvulus		0.0061	0.3812	0.5
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0077	0.5982	0.8196
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.3812	0.5223
Schistosoma mansoni	hypothetical protein	0.0061	0.3812	0.5223
Brugia malayi	G protein-coupled receptor F59B2.13	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus granulosus	neuropeptides capa receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0034	0.0008	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0086	0.7299	0.5
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	neuropeptide receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	glycosyltransferase protein LARGE2	0.0077	0.5982	0.8196
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0077	0.5982	0.8196
Schistosoma mansoni	histamine h1 receptor	0.0061	0.3812	0.5223
Brugia malayi	sulfakinin receptor protein	0.0061	0.3812	0.3812
Echinococcus granulosus	neuropeptide receptor	0.0061	0.3812	0.5223
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0086	0.7299	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0061	0.3812	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0061	0.3812	0.5223
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0061	0.3812	0.5223
Brugia malayi	AKH receptor	0.0061	0.3812	0.3812
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	Dopamine receptor	0.0061	0.3812	0.3812
Echinococcus multilocularis	neuropeptide s receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	neuropeptide Y receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	opsin-like receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0072	0.5371	0.5371
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0061	0.3812	0.5223
Echinococcus granulosus	7TM GPCR rhodopsin	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0061	0.3812	0.5223
Schistosoma mansoni	amine GPCR	0.0061	0.3812	0.5223
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	g protein coupled receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	G-protein coupled receptor	0.0061	0.3812	0.3812
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0034	0.0008	0.0008
Echinococcus granulosus	somatostatin receptor	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Brugia malayi	putative neuropeptide receptor	0.0061	0.3812	0.3812
Onchocerca volvulus		0.0061	0.3812	0.5
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0057	0.3189	0.437
Echinococcus granulosus	fmrfamide receptor	0.0061	0.3812	0.5223
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0057	0.3189	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	TYRA-2 protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0008	0.001
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0061	0.3812	0.5223
Echinococcus multilocularis	Glycosyl transferase, family 8	0.0079	0.633	0.8673
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0061	0.3812	0.3812
Onchocerca volvulus		0.0061	0.3812	0.5
Echinococcus granulosus	orexin receptor type 2	0.0061	0.3812	0.5223
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0034	0.0008	0.001
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	g-protein coupled receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	somatostatin receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0086	0.7299	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	amine GPCR	0.0061	0.3812	0.5223
Schistosoma mansoni	neuropeptide f receptor 76f	0.0061	0.3812	0.5223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0061	0.3812	0.5223
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus granulosus	dro:myosuppressin receptor	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Brugia malayi	Serotonin receptor	0.0061	0.3812	0.3812
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0061	0.3812	0.3812
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0061	0.3812	0.5223
Echinococcus multilocularis	fmrfamide receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.3812	0.5223
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0061	0.3812	0.5223
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0008	0.5
Schistosoma mansoni	biogenic amine receptor	0.0061	0.3812	0.5223
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0008	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0061	0.3812	0.5223
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0086	0.7299	0.5
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0008	0.001
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.3812	0.5223
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0061	0.3812	0.3812
Echinococcus granulosus	biogenic amine 5HT receptor	0.0061	0.3812	0.5223
Brugia malayi	follicle stimulating hormone receptor	0.0061	0.3812	0.3812
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	neuropeptide Y receptor	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0061	0.3812	0.5223
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0086	0.7299	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0061	0.3812	0.3812
Schistosoma mansoni	hypothetical protein	0.0072	0.5371	0.736
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	serotonin receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Echinococcus multilocularis	conserved hypothetical protein	0.0059	0.3503	0.48
Echinococcus multilocularis	neuropeptides capa receptor	0.0061	0.3812	0.5223
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.5371	0.5371
Brugia malayi	neuropeptide F receptor	0.0061	0.3812	0.3812
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0061	0.3812	0.5223
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.3812	0.5223
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	opsin-like receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0061	0.3812	0.5223
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0061	0.3812	0.3812
Echinococcus granulosus	neuropeptide FF receptor 2	0.0061	0.3812	0.5223
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	neuropeptide s receptor	0.0061	0.3812	0.5223
Brugia malayi	Glycosyl transferase family 8 protein	0.0079	0.633	0.633
Onchocerca volvulus		0.0061	0.3812	0.5
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	GnHR receptor homolog	0.0061	0.3812	0.3812
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0061	0.3812	0.5223
Brugia malayi	Dopamine receptor protein 2	0.0061	0.3812	0.3812
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0061	0.3812	0.5223
Brugia malayi	Melatonin receptor type 1A	0.0061	0.3812	0.3812
Echinococcus multilocularis	neuropeptide Y receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	biogenic amine receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0034	0.0008	0.5
Echinococcus multilocularis	glycosyltransferase protein LARGE2	0.0077	0.5982	0.8196
Loa Loa (eye worm)	neuropeptide F receptor	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	neuropeptide F receptor	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0086	0.7299	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Brugia malayi	RE15519p	0.0061	0.3812	0.3812
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Schistosoma mansoni	hypothetical protein	0.0061	0.3812	0.5223
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	serotonin receptor	0.0061	0.3812	0.5223
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0061	0.3812	0.3812
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	neuropeptide Y receptor	0.0061	0.3812	0.5223
Brugia malayi	isocitrate dehydrogenase	0.0034	0.0008	0.0008
Echinococcus granulosus	hypothetical protein	0.0061	0.3812	0.5223
Brugia malayi	G protein-coupled receptor	0.0061	0.3812	0.3812
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	myosin xvIII	0.0061	0.3812	0.5223
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.3812	0.5223
Loa Loa (eye worm)	glycosyl transferase family 8 protein	0.0079	0.633	0.633
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	Serotonin receptor	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus granulosus	neuropeptide receptor A26	0.0061	0.3812	0.5223
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	neuropeptide receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	neuropeptide F-like receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	biogenic amine receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	fmrfamide receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	glycosyltransferase-related	0.0079	0.633	0.8673
Onchocerca volvulus		0.0061	0.3812	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Echinococcus multilocularis	serotonin receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	hypothetical protein	0.0061	0.3812	0.5223
Schistosoma mansoni	neuropeptide F-like receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	Glycosyltransferase protein LARGE1	0.0059	0.3503	0.48
Brugia malayi	Dopamine receptor protein 1	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0057	0.3189	1
Echinococcus granulosus	g protein coupled receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	amine GPCR	0.0061	0.3812	0.5223
Echinococcus multilocularis	sex peptide receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3812	0.5223
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0086	0.7299	0.5
Brugia malayi	Probable ClpP-like protease	0.0086	0.7299	0.7299
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Schistosoma mansoni	peptidase Clp (S14 family)	0.0086	0.7299	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0061	0.3812	0.5223
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	amine GPCR	0.0061	0.3812	0.5223
Schistosoma mansoni	amine GPCR	0.0061	0.3812	0.5223
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0034	0.0008	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0061	0.3812	0.5223
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0086	0.7299	0.7299
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0061	0.3812	0.3812
Brugia malayi	putative neuropeptide receptor NPR1	0.0061	0.3812	0.3812
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus granulosus	Glycosyltransferase protein LARGE1	0.0059	0.3503	0.48
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus granulosus	peptidase Clp S14 family	0.0057	0.3189	0.437
Schistosoma mansoni	growth hormone secretagogue receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	neuropeptides capa receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3812	0.5223
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.3812	0.5223
Echinococcus granulosus	allatostatin A receptor	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0061	0.3812	0.5223
Echinococcus multilocularis	dro:myosuppressin receptor	0.0061	0.3812	0.5223
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0034	0.0008	0.5
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0086	0.7299	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	adenoreceptor	0.0061	0.3812	0.5223
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0086	0.7299	0.5
Onchocerca volvulus		0.0061	0.3812	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0061	0.3812	0.5
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0061	0.3812	0.5223
Echinococcus granulosus	neuropeptides capa receptor	0.0061	0.3812	0.5223
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0106	1	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus granulosus	g-protein coupled receptor	0.0061	0.3812	0.5223
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0034	0.0008	0.001
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.3812	0.5223
Echinococcus granulosus	7tm_1 domain containing protein	0.0061	0.3812	0.5223
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus granulosus	G protein coupled receptor 139	0.0061	0.3812	0.5223
Schistosoma mansoni	hypothetical protein	0.0061	0.3812	0.5223
Echinococcus multilocularis	neuropeptide receptor	0.0061	0.3812	0.5223
Schistosoma mansoni	opsin-like receptor	0.0061	0.3812	0.5223
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	G-protein coupled receptor	0.0061	0.3812	0.3812
Brugia malayi	larval opioid receptor	0.0061	0.3812	0.3812
Echinococcus multilocularis	orexin receptor type 2	0.0061	0.3812	0.5223
Loa Loa (eye worm)	melatonin receptor type 1A	0.0061	0.3812	0.3812
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0061	0.3812	0.5223
Brugia malayi	ORL1-like opioid receptor	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0086	0.7299	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3812	0.3812
Brugia malayi	hypothetical protein	0.0061	0.3812	0.3812
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0061	0.3812	0.5223
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.3812	0.5223
Onchocerca volvulus		0.0061	0.3812	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3186091

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1874298