Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.2092 | 0.5669 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3485 | 0.9822 | 0.9822 |
Mycobacterium ulcerans | hypothetical protein | 0.2092 | 0.5669 | 0.5 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2092 | 0.5669 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3485 | 0.9822 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3545 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3485 | 0.9822 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3545 | 1 | 1 |
Onchocerca volvulus | 0.3545 | 1 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.2092 | 0.5669 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3545 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3545 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2092 | 0.5669 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3485 | 0.9822 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1513 | 0.3941 | 0.3941 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3545 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3545 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3545 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3485 | 0.9822 | 0.9604 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 34 % | Inhibition of cPLA2 measuring Calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets with HPLC/UV detection. at 3.3 microM concentration. | ChEMBL. | 9341913 |
Inhibition (functional) | = 34 % | Inhibition of cPLA2 measuring Calcium ionophore A-23,187-induced arachidonic acid release from bovine platelets with HPLC/UV detection. at 3.3 microM concentration. | ChEMBL. | 9341913 |
Lysis (functional) | = 42 % | Percentage platelet cell lysis at 33 microM measured by turbidimetry. | ChEMBL. | 9341913 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.