Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0.0029 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0029 | 0.0029 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0029 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.0029 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0039 | 0.4871 | 0.4871 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0039 | 0.4871 | 0.4871 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0029 | 0.0029 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0029 | 0.0029 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0039 | 0.4871 | 0.4871 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0039 | 0.4871 | 0.4871 |
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0029 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0029 | 0.0029 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.0029 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.4871 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4871 | 0.4871 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ke (binding) | = 963 nM | Antagonist activity at human 5-HT2A receptor assessed as inhibition of 5-HT-induced mobilization of internal calcium at 10 uM by FLIPR assay | ChEMBL. | 24630561 |
Ke (binding) | > 3000 nM | Antagonist activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of mobilization of internal calcium at 10 uM by FLIPR assay | ChEMBL. | 24630561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.