Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | TGF beta receptor type 1 | 0.0108 | 0.2247 | 0.3652 |
Brugia malayi | Protein kinase domain containing protein | 0.0275 | 0.6154 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0275 | 0.6154 | 1 |
Schistosoma mansoni | plexin | 0.0011 | 0.0005 | 0.0021 |
Onchocerca volvulus | 0.002 | 0.0195 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.602 | 0.9783 |
Echinococcus granulosus | plexin a4 | 0.0023 | 0.0278 | 0.0452 |
Echinococcus granulosus | activin receptor type | 0.0113 | 0.2381 | 0.3869 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0005 | 0.0021 |
Schistosoma mansoni | protein kinase | 0.0108 | 0.2247 | 0.9439 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0108 | 0.2247 | 0.2247 |
Schistosoma mansoni | plexin | 0.002 | 0.0195 | 0.082 |
Echinococcus multilocularis | activin receptor type | 0.0113 | 0.2381 | 0.2381 |
Loa Loa (eye worm) | plexin A | 0.0023 | 0.0278 | 0.0445 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0108 | 0.2247 | 0.3652 |
Schistosoma mansoni | protein kinase | 0.0113 | 0.2381 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0023 | 0.0278 | 0.0278 |
Brugia malayi | plexin A | 0.0023 | 0.0278 | 0.014 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0275 | 0.6154 | 0.6154 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0195 | 0.0309 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0113 | 0.2381 | 0.3668 |
Echinococcus granulosus | tyrosine protein kinase | 0.0275 | 0.6154 | 1 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0113 | 0.2381 | 0.3864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.