Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0112 | 0.2247 | 0.9439 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0112 | 0.2247 | 0.2247 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0005 | 0.0021 |
Schistosoma mansoni | plexin | 0.002 | 0.0195 | 0.082 |
Echinococcus granulosus | plexin a4 | 0.0024 | 0.0278 | 0.0452 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.602 | 0.9783 |
Echinococcus granulosus | activin receptor type | 0.0118 | 0.2381 | 0.3869 |
Loa Loa (eye worm) | TK protein kinase | 0.0287 | 0.6154 | 1 |
Onchocerca volvulus | 0.002 | 0.0195 | 0.5 | |
Schistosoma mansoni | plexin | 0.0012 | 0.0005 | 0.0021 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0112 | 0.2247 | 0.3652 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.6154 | 1 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0118 | 0.2381 | 0.3668 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0195 | 0.0309 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0287 | 0.6154 | 0.6154 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0118 | 0.2381 | 0.3864 |
Echinococcus granulosus | tyrosine protein kinase | 0.0287 | 0.6154 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0024 | 0.0278 | 0.0278 |
Brugia malayi | plexin A | 0.0024 | 0.0278 | 0.014 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0112 | 0.2247 | 0.3652 |
Schistosoma mansoni | protein kinase | 0.0118 | 0.2381 | 1 |
Echinococcus multilocularis | activin receptor type | 0.0118 | 0.2381 | 0.2381 |
Loa Loa (eye worm) | plexin A | 0.0024 | 0.0278 | 0.0445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.