Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0045 | 0.0734 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0045 | 0.0734 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0045 | 0.0734 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0045 | 0.0734 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0045 | 0.0734 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0045 | 0.0734 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0045 | 0.0734 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0045 | 0.0734 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 0.0734 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0057 | 1 | 1 |
Trypanosoma brucei | wee1-like protein kinase | 0.0057 | 1 | 1 |
Brugia malayi | cell division control protein 2 homolog | 0.0045 | 0.0734 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 0.0734 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0045 | 0.0734 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0045 | 0.0734 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0045 | 0.0734 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0045 | 0.0734 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0045 | 0.0734 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0734 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0057 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0045 | 0.0734 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0734 | 0.5 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0057 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0045 | 0.0734 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0045 | 0.0734 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0045 | 0.0734 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0045 | 0.0734 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0045 | 0.0734 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0045 | 0.0734 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.