Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0054 | 0.0448 | 0.002 |
Trichomonas vaginalis | STE family protein kinase | 0.0054 | 0.0448 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0054 | 0.0448 | 1 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0053 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0053 | 0.0431 | 0.0431 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0054 | 0.0448 | 0.002 |
Trichomonas vaginalis | STE family protein kinase | 0.0054 | 0.0448 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0054 | 0.0448 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0054 | 0.0448 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0431 | 0.0431 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0565 | 0.9107 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0054 | 0.0448 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0054 | 0.0448 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0054 | 0.0448 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0054 | 0.0448 | 1 |
Schistosoma mansoni | protein kinase | 0.0054 | 0.0448 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0054 | 0.0448 | 0.002 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0565 | 0.9107 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0054 | 0.0448 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0054 | 0.0448 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0054 | 0.0448 | 0.002 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0618 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0054 | 0.0448 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0054 | 0.0448 | 0.002 |
Brugia malayi | WH1 domain containing protein | 0.0053 | 0.0431 | 0.0431 |
Schistosoma mansoni | protein kinase | 0.0054 | 0.0448 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0054 | 0.0448 | 0.002 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0053 | 0.0431 | 0.0431 |
Entamoeba histolytica | protein kinase, putative | 0.0054 | 0.0448 | 1 |
Brugia malayi | Protein kinase domain | 0.0054 | 0.0448 | 0.0448 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 14.12537545 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.