Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypoxia- inducible factor prolyl hydroxylase (phd2), putative | 0.0497 | 0 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0497 | 0 | 0.5 |
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0497 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0497 | 0 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0497 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.3137 | 0.3211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3137 | 0.3211 | 0.3211 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0497 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.3137 | 0.3211 | 1 |
Toxoplasma gondii | tetratricopeptide repeat-containing protein | 0.0497 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3187 | 0.3273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3137 | 0.3211 | 0.3211 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.3137 | 0.3211 | 1 |
Onchocerca volvulus | 0.0497 | 0 | 0.5 | |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.3137 | 0.3211 | 0.3211 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0497 | 0 | 0.5 |
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0497 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 28 % | Percent purine accumulated in human B lymphoblast WI-L2 cells cultured medium was determined | ChEMBL. | 3123692 |
Activity (functional) | = 48 % | Percent purine synthesized in human B lymphoblast WI-L2 cells was determined | ChEMBL. | 3123692 |
Ki (binding) | 0 uM | Inhibitory activity against purine nucleoside phosphorylase (PNPase); E means not determined | ChEMBL. | 3123692 |
Ratio (functional) | = 2.4 | Adenylate to guanylate ratio for the cell fraction was determined | ChEMBL. | 3123692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.