Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0033 | 0.0067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.2638 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0067 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0067 | 0.0067 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0067 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0067 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0067 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0067 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0067 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0067 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0067 | 0.0067 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0067 | 0.0058 |
Schistosoma mansoni | lamin | 0.0033 | 0.0067 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.0067 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0067 | 0.0067 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0067 | 1 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.2638 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0009 | 0.0009 |
Onchocerca volvulus | 0.0033 | 0.0067 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.2638 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.