TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.32 | Formula: C18H18Cl2N2S
H donors: 1 H acceptors: 0 LogP: 4.68 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NCCC/N=c/1\cc(sc2c1cc(Cl)cc2)c1ccccc1.Cl
InChi: 1S/C18H17ClN2S.ClH/c19-14-7-8-17-15(11-14)16(21-10-4-9-20)12-18(22-17)13-5-2-1-3-6-13;/h1-3,5-8,11-12H,4,9-10,20H2;1H/b21-16+;
InChiKey: DJOOVTCKGHUMRB-JEBHESKQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0549	0.0215
Echinococcus granulosus	g protein coupled receptor	0.001	0.0392	0.0206
Echinococcus granulosus	neuropeptide receptor	0.001	0.0392	0.0206
Brugia malayi	GnHR receptor homolog	0.001	0.0392	0.0206
Loa Loa (eye worm)	neuropeptide F receptor	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0043	0.3975	0.3859
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0623	0.078
Brugia malayi	steroid hormone receptor	0.0012	0.0549	0.0366
Echinococcus granulosus	g protein coupled receptor	0.001	0.0392	0.0206
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0043	0.3975	0.3859
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0392	0.049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0549	0.0687
Loa Loa (eye worm)	melatonin receptor type 1A	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.001	0.0392	0.049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Echinococcus granulosus	tm gpcr rhodopsin	0.001	0.0392	0.0206
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Brugia malayi	ORL1-like opioid receptor	0.001	0.0392	0.0206
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Loa Loa (eye worm)	neuropeptide F receptor	0.001	0.0392	0.0212
Echinococcus multilocularis	serotonin receptor	0.001	0.0392	0.0206
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.001	0.0392	0.0206
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.001	0.0392	0.0206
Echinococcus multilocularis	dro:myosuppressin receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.0623	0.0442
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	Dopamine receptor protein 2	0.001	0.0392	0.0206
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.4409	0.552
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	orexin receptor type 2	0.001	0.0392	0.0206
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0549	0.0378
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.001	0.0392	0.0206
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0043	0.3975	0.3978
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0392	0.049
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0623	0.0456
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.001	0.0392	0.0212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0549	0.0366
Schistosoma mansoni	neuropeptide receptor	0.001	0.0392	0.049
Schistosoma mansoni	neuropeptide f receptor 76f	0.001	0.0392	0.049
Echinococcus multilocularis	neuropeptide receptor A26	0.001	0.0392	0.0206
Echinococcus multilocularis	neuropeptides capa receptor	0.001	0.0392	0.0206
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0008	0.019	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus granulosus	biogenic amine 5HT receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.019	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Echinococcus multilocularis	allatostatin A receptor	0.001	0.0392	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0549	0.0366
Schistosoma mansoni	biogenic amine (5HT) receptor	0.001	0.0392	0.049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0549	0.0215
Brugia malayi	sulfakinin receptor protein	0.001	0.0392	0.0206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Echinococcus granulosus	neuropeptide s receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Echinococcus multilocularis	g-protein coupled receptor	0.001	0.0392	0.0206
Echinococcus granulosus	7tm_1 domain containing protein	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0549	0.0366
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	adenoreceptor	0.001	0.0392	0.049
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.001	0.0392	0.049
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.001	0.0392	0.0212
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0549	0.0366
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0549	0.0378
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.019	0.0237
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0549	0.0687
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.001	0.0392	0.049
Schistosoma mansoni	hypothetical protein	0.001	0.0392	0.049
Brugia malayi	follicle stimulating hormone receptor	0.001	0.0392	0.0206
Onchocerca volvulus		0.0012	0.0549	0.0215
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0012	0.0623	0.0442
Brugia malayi	putative neuropeptide receptor NPR1	0.001	0.0392	0.0206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	fmrfamide receptor	0.001	0.0392	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0549	0.0366
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.001	0.0392	0.0206
Schistosoma mansoni	amine GPCR	0.001	0.0392	0.049
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Echinococcus granulosus	hypothetical protein	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	nuclear hormone receptor	0.0012	0.0549	0.0366
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.001	0.0392	0.049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.001	0.0392	0.049
Echinococcus multilocularis	voltage gated potassium channel	0.0012	0.0623	0.0442
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Echinococcus multilocularis	jun protein	0.0098	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.001	0.0392	0.0206
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0549	0.0366
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0549	0.0366
Schistosoma mansoni	coup transcription factor	0.0012	0.0549	0.0687
Schistosoma mansoni	biogenic amine receptor	0.001	0.0392	0.049
Echinococcus granulosus	tm gpcr rhodopsin	0.001	0.0392	0.0206
Schistosoma mansoni	opsin-like receptor	0.001	0.0392	0.049
Schistosoma mansoni	amine GPCR	0.001	0.0392	0.049
Echinococcus granulosus	voltage gated potassium channel	0.0012	0.0623	0.0442
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.001	0.0392	0.0206
Echinococcus granulosus	g protein coupled receptor	0.001	0.0392	0.0206
Echinococcus granulosus	allatostatin A receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	G-protein coupled receptor, putative	0.001	0.0392	0.0206
Echinococcus multilocularis	somatostatin receptor	0.001	0.0392	0.0206
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0549	0.0366
Echinococcus granulosus	tm gpcr rhodopsin	0.001	0.0392	0.0206
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.019	0.0237
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.001	0.0392	0.0206
Echinococcus multilocularis	neuropeptides capa receptor	0.001	0.0392	0.0206
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0549	0.0687
Schistosoma mansoni	alpha-1 adrenergic receptor	0.001	0.0392	0.049
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0549	0.0687
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.001	0.0392	0.0206
Echinococcus granulosus	neuropeptides capa receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0037	0.3352	0.3323
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.001	0.0392	0.049
Echinococcus multilocularis	neuropeptide s receptor	0.001	0.0392	0.0206
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.001	0.0392	0.0206
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.4409	0.552
Schistosoma mansoni	opsin-like receptor	0.001	0.0392	0.049
Echinococcus multilocularis	g protein coupled receptor	0.001	0.0392	0.0206
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0549	0.0366
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0549	0.0378
Echinococcus granulosus	dro:myosuppressin receptor	0.001	0.0392	0.0206
Schistosoma mansoni	hypothetical protein	0.001	0.0392	0.049
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0549	0.0366
Brugia malayi	AKH receptor	0.001	0.0392	0.0206
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.0623	0.0442
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0549	0.0366
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	fmrfamide receptor	0.001	0.0392	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0549	0.0366
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.001	0.0392	0.0206
Echinococcus granulosus	peptide allatostatin:somatostatin	0.001	0.0392	0.0206
Schistosoma mansoni	neuropeptide receptor	0.001	0.0392	0.049
Echinococcus granulosus	alpha 1A adrenergic receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus multilocularis	neuropeptide Y receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.001	0.0392	0.049
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.001	0.0392	0.0212
Schistosoma mansoni	growth hormone secretagogue receptor	0.001	0.0392	0.049
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.001	0.0392	0.0206
Schistosoma mansoni	biogenic amine (5HT) receptor	0.001	0.0392	0.049
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0549	0.0366
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0549	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Echinococcus multilocularis	serotonin receptor	0.001	0.0392	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0549	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	Tachykinin-like peptides receptor 99D	0.001	0.0392	0.0206
Brugia malayi	RE15519p	0.001	0.0392	0.0206
Schistosoma mansoni	neuropeptide receptor	0.001	0.0392	0.049
Echinococcus multilocularis	g protein coupled receptor	0.001	0.0392	0.0206
Schistosoma mansoni	neuropeptide receptor	0.001	0.0392	0.049
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0549	0.0687
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0549	0.0366
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0549	0.0366
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0549	0.0366
Echinococcus multilocularis	neuropeptide FF receptor 2	0.001	0.0392	0.0206
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.001	0.0392	0.0212
Echinococcus granulosus	neuropeptide FF receptor 2	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0549	0.0366
Brugia malayi	Serotonin receptor	0.001	0.0392	0.0206
Brugia malayi	ecdysteroid receptor	0.0012	0.0549	0.0366
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0549	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Schistosoma mansoni	opsin-like receptor	0.001	0.0392	0.049
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0549	0.0378
Brugia malayi	neuropeptide F receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	larval opioid receptor	0.001	0.0392	0.0206
Echinococcus multilocularis	G protein coupled receptor 139	0.001	0.0392	0.0206
Schistosoma mansoni	neuropeptide F-like receptor	0.001	0.0392	0.049
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.001	0.0392	0.049
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0549	0.0687
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	amine GPCR	0.001	0.0392	0.049
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.3665	1
Schistosoma mansoni	hypothetical protein	0.0079	0.7987	1
Schistosoma mansoni	neuropeptide F-like receptor	0.001	0.0392	0.049
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0549	0.0366
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Echinococcus multilocularis	neuropeptide receptor	0.001	0.0392	0.0206
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0549	0.0366
Echinococcus granulosus	G protein coupled receptor 139	0.001	0.0392	0.0206
Brugia malayi	neuropeptide F receptor	0.001	0.0392	0.0206
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.019	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Brugia malayi	Melatonin receptor type 1A	0.001	0.0392	0.0206
Echinococcus multilocularis	g protein coupled receptor	0.001	0.0392	0.0206
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.001	0.0392	0.0206
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0549	0.0378
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	histamine h1 receptor	0.001	0.0392	0.049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0549	0.0378
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0549	0.0366
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.001	0.0392	0.0206
Echinococcus granulosus	tachykinin peptides receptor 99D	0.001	0.0392	0.0206
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0043	0.3975	0.3859
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.001	0.0392	0.0206
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Echinococcus multilocularis	neuropeptide receptor	0.001	0.0392	0.0206
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0549	0.0687
Brugia malayi	Dopamine receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Echinococcus granulosus	fmrfamide receptor	0.001	0.0392	0.0206
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.001	0.0392	0.0206
Schistosoma mansoni	hypothetical protein	0.001	0.0392	0.049
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0549	0.0366
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.001	0.0392	0.0206
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0008	0.019	0.0237
Loa Loa (eye worm)	TYRA-2 protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Schistosoma mansoni	hypothetical protein	0.001	0.0392	0.049
Schistosoma mansoni	biogenic amine receptor	0.001	0.0392	0.049
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0549	0.0366
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0549	0.0366
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0549	0.0687
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.001	0.0392	0.0206
Schistosoma mansoni	amine GPCR	0.001	0.0392	0.049
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0549	0.0366
Echinococcus granulosus	serotonin receptor	0.001	0.0392	0.0206
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0549	0.0687
Schistosoma mansoni	biogenic amine receptor	0.001	0.0392	0.049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0549	0.0366
Echinococcus granulosus	neuropeptide Y receptor	0.001	0.0392	0.0206
Loa Loa (eye worm)	G-protein coupled receptor	0.001	0.0392	0.0212
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0549	0.0215
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0549	0.0366
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0549	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0549	0.0378
Loa Loa (eye worm)	G-protein coupled receptor	0.001	0.0392	0.0212
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Echinococcus granulosus	somatostatin receptor	0.001	0.0392	0.0206
Echinococcus granulosus	sex peptide receptor	0.001	0.0392	0.0206
Schistosoma mansoni	jun-related protein	0.0079	0.7987	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Echinococcus granulosus	neuropeptides capa receptor	0.001	0.0392	0.0206
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.001	0.0392	0.049
Echinococcus granulosus	neuropeptide Y receptor	0.001	0.0392	0.0206
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Echinococcus granulosus	biogenic amine 5HT receptor	0.001	0.0392	0.0206
Echinococcus granulosus	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Brugia malayi	Serotonin receptor	0.001	0.0392	0.0206
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.001	0.0392	0.049
Brugia malayi	G protein-coupled receptor	0.001	0.0392	0.0206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Echinococcus granulosus	7TM GPCR rhodopsin	0.001	0.0392	0.0206
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	putative neuropeptide receptor	0.001	0.0392	0.0206
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0392	0.049
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0623	0.078
Brugia malayi	Dopamine receptor protein 1	0.001	0.0392	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0549	0.0366
Echinococcus multilocularis	sex peptide receptor	0.001	0.0392	0.0206
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0549	0.0366
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0549	0.0366
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0549	0.0366
Echinococcus granulosus	jun protein	0.0098	1	1
Echinococcus granulosus	g-protein coupled receptor	0.001	0.0392	0.0206
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0549	0.0366
Echinococcus multilocularis	rhodopsin orphan GPCR	0.001	0.0392	0.0206
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0549	0.0687
Schistosoma mansoni	myosin xvIII	0.001	0.0392	0.049
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0549	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0095	0.9705	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0549	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0549	0.0378
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.3665	1
Echinococcus multilocularis	neuropeptide Y receptor	0.001	0.0392	0.0206
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.001	0.0392	0.0206
Echinococcus granulosus	neuropeptide receptor	0.001	0.0392	0.0206
Echinococcus granulosus	neuropeptide receptor A26	0.001	0.0392	0.0206
Onchocerca volvulus		0.0077	0.7693	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0392	0.0212
Brugia malayi	G-protein coupled receptor	0.001	0.0392	0.0206
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.001	0.0392	0.0206
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0392	0.049
Echinococcus granulosus	orexin receptor type 2	0.001	0.0392	0.0206
Schistosoma mansoni	amine GPCR	0.001	0.0392	0.049
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0098	1	1
Brugia malayi	hypothetical protein	0.0077	0.7693	0.7648
Brugia malayi	hypothetical protein	0.001	0.0392	0.0206
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0098	1	1
Brugia malayi	G-protein coupled receptor	0.001	0.0392	0.0206
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0549	0.0366

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3248985

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1892815