Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0248 | 0.826 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0223 | 0.6945 | 0.6945 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Echinococcus granulosus | histone deacetylase 7 | 0.0223 | 0.6945 | 0.8401 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0107 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0248 | 0.826 | 0.826 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Echinococcus granulosus | histone deacetylase 3 | 0.0248 | 0.826 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0248 | 0.826 | 0.826 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Echinococcus granulosus | histone deacetylase | 0.0223 | 0.6945 | 0.8401 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0248 | 0.826 | 0.826 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0732 | 0.0732 |
Giardia lamblia | Histone deacetylase | 0.0248 | 0.826 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.161 | 0.161 |
Echinococcus granulosus | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8401 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8409 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.127 | 0.127 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0107 | 0.0732 | 0.0732 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0248 | 0.826 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0223 | 0.6945 | 0.8254 |
Schistosoma mansoni | histone deacetylase | 0.0248 | 0.826 | 0.826 |
Plasmodium vivax | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Trypanosoma brucei | histone deacetylase 4 | 0.0223 | 0.6945 | 0.8254 |
Schistosoma mansoni | serine/threonine kinase | 0.0281 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.023 | 0.7286 | 0.8815 |
Echinococcus multilocularis | histone deacetylase | 0.0223 | 0.6945 | 0.8409 |
Echinococcus granulosus | histone deacetylase 8 | 0.0107 | 0.0732 | 0.0844 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Leishmania major | histone deacetylase, putative | 0.0248 | 0.826 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8409 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0248 | 0.826 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0107 | 0.0732 | 0.0732 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0223 | 0.6945 | 0.8409 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0094 | 0.0037 | 0.0045 |
Brugia malayi | Histone deacetylase family protein | 0.0223 | 0.6945 | 0.6945 |
Trypanosoma brucei | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.826 | 0.826 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0094 | 0.0037 | 0.0045 |
Brugia malayi | Histone deacetylase family protein | 0.0223 | 0.6945 | 0.6945 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Leishmania major | histone deacetylase, putative | 0.0248 | 0.826 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0248 | 0.826 | 0.648 |
Trypanosoma brucei | histone deacetylase 3 | 0.0223 | 0.6945 | 0.8254 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0248 | 0.826 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0107 | 0.0732 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0223 | 0.6945 | 0.6945 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0223 | 0.6945 | 0.8254 |
Entamoeba histolytica | histone deacetylase, putative | 0.0248 | 0.826 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8401 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0281 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0248 | 0.826 | 0.648 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0188 | 0.5056 | 0.6104 |
Brugia malayi | histone deacetylase 11 | 0.0107 | 0.0732 | 0.0732 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0223 | 0.6945 | 0.6945 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0248 | 0.826 | 0.826 |
Echinococcus granulosus | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0248 | 0.826 | 0.648 |
Brugia malayi | Histone deacetylase 1 | 0.0248 | 0.826 | 0.826 |
Loa Loa (eye worm) | histone deacetylase | 0.0223 | 0.6945 | 0.6945 |
Schistosoma mansoni | histone deacetylase hda2 | 0.023 | 0.7286 | 0.7286 |
Schistosoma mansoni | histone deacetylase | 0.0248 | 0.826 | 0.826 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0188 | 0.5056 | 0.6121 |
Echinococcus multilocularis | histone deacetylase 6 | 0.023 | 0.7286 | 0.8821 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0107 | 0.0732 | 0.0886 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0248 | 0.826 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0248 | 0.826 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0094 | 0.0037 | 0.0045 |
Trypanosoma brucei | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 0.67 mmol/Kg | Toxicity in ip dosed BDF1 mouse assessed as animal killed administered as single dose | ChEMBL. | 722732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.