Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1939 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.1018 | 0 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.1939 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1939 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1939 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.1939 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.1939 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.1018 | 0 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.1018 | 0 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1939 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1939 | 1 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.1018 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.1018 | 0 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.1018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 35 mg kg-1 | Acute toxicity in iv dosed mouse | ChEMBL. | 17752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.