Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | PAN domain-containing protein | 0.0298 | 0.1556 | 1 |
Echinococcus granulosus | Mastin | 0.0529 | 0.4602 | 0.4602 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0937 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0456 | 0.3643 | 0.3643 |
Echinococcus multilocularis | serotonin transporter | 0.0456 | 0.3643 | 0.3643 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3643 | 0.3643 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3643 | 0.3643 |
Echinococcus granulosus | serotonin transporter | 0.0456 | 0.3643 | 0.3643 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0456 | 0.3643 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0529 | 0.4602 | 0.4602 |
Toxoplasma gondii | PAN domain-containing protein | 0.0298 | 0.1556 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0456 | 0.3643 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0456 | 0.3643 | 0.3643 |
Echinococcus multilocularis | Mastin | 0.0529 | 0.4602 | 0.4602 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0456 | 0.3643 | 0.3643 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0529 | 0.4602 | 0.4602 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 1 | 1 |
Onchocerca volvulus | 0.0456 | 0.3643 | 1 | |
Echinococcus multilocularis | serotonin receptor | 0.0937 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0456 | 0.3643 | 0.3643 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0529 | 0.4602 | 0.4602 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0529 | 0.4602 | 0.4602 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0456 | 0.3643 | 0.3643 |
Echinococcus multilocularis | enteropeptidase | 0.0529 | 0.4602 | 0.4602 |
Echinococcus multilocularis | serotonin receptor | 0.0937 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3643 | 0.3643 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 10 ug ml-1 | Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition | ChEMBL. | 406398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.