Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alanyl (membrane) aminopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | alanyl (membrane) aminopeptidase | 967 aa | 976 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Onchocerca volvulus | 0.0102 | 0.593 | 0.593 | |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.7295 | 0.8549 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0112 | 0.6916 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0052 | 0.0986 | 0.1426 |
Onchocerca volvulus | 0.0112 | 0.6916 | 0.6916 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6916 | 0.8104 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0112 | 0.6916 | 0.6916 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0112 | 0.6916 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 1 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6916 | 0.8104 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11 nM | Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | ChEMBL. | 24927250 |
Ki (binding) | = 11 nM | Inhibition of recombinant human Aminopeptidase N using L-Ala-beta-NA as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorometry | ChEMBL. | 26241877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.