Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alanyl (membrane) aminopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | alanyl (membrane) aminopeptidase | 967 aa | 976 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7148 | 0.8376 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0114 | 0.7148 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0114 | 0.7148 | 0.7148 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5828 | 0.683 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.7148 | 0.8376 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0114 | 0.7148 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.7295 | 0.8549 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0052 | 0.1007 | 0.1409 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0042 | 0 | 0.5 |
Onchocerca volvulus | 0.0114 | 0.7148 | 0.7148 | |
Onchocerca volvulus | 0.0143 | 1 | 1 | |
Onchocerca volvulus | 0.0104 | 0.6141 | 0.6141 | |
Trypanosoma cruzi | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 13 nM | Inhibition of human recombinant APN using L-Ala-beta-NA as substrate after 30 mins by fluorimetry | ChEMBL. | 24927250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.