Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Onchocerca volvulus | Chitinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 1 | 0.5 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0091 | 0.8652 | 0.5389 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0102 | 0.9942 | 1 |
Leishmania major | chitinase | 0.0091 | 0.8652 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0102 | 1 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Mycobacterium tuberculosis | Possible chitinase | 0.0078 | 0.7077 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0078 | 0.7077 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0102 | 0.9942 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0102 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1693 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.0032 | 0.1693 | 0.5 |
Entamoeba histolytica | chitinase, putative | 0.0091 | 0.8652 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0102 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0102 | 0.9942 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0091 | 0.8652 | 0.5389 |
Trypanosoma brucei | glucose transporter 1E | 0.0032 | 0.1693 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1693 | 1 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0088 | 0.8367 | 0.4412 |
Brugia malayi | endochitinase | 0.0102 | 0.9942 | 0.9569 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1693 | 1 |
Brugia malayi | Endochitinase | 0.0102 | 0.9942 | 0.9569 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0102 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0102 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 1 | 0.5 |
Trypanosoma cruzi | hexose transporter | 0.0032 | 0.1693 | 1 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0078 | 0.7077 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.99 uM | Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis | ChEMBL. | 24918716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.