Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine protease, putative | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0123 | 0.3066 | 0.3066 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0848 | 0.0848 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Loa Loa (eye worm) | fibroinase | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0123 | 0.3066 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0035 | 0.0488 | 0.3182 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus multilocularis | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | cathepsin B | 0.0123 | 0.3066 | 0.3066 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | Cathepsin F homolog | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Echinococcus granulosus | cysteine protease | 0.003 | 0.0321 | 0.0321 |
Echinococcus granulosus | cathepsin l1 | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Toxoplasma gondii | cathepsin B | 0.0123 | 0.3066 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0048 | 0.0848 | 0.0848 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0048 | 0.0848 | 0.0544 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0035 | 0.0488 | 0.0488 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0123 | 0.3066 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0123 | 0.3066 | 0.2836 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0035 | 0.0488 | 0.5762 | |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0359 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin l1 | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0359 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0035 | 0.0488 | 0.0173 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0123 | 0.3066 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0488 | 0.0488 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0048 | 0.0848 | 0.0848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 12 mg kg-1 | Antiwrithing activity in sc dosed mouse assessed as prevention of acetylcholine-induced abdominal constriction response | ChEMBL. | 31481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.