Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0359 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0035 | 0.0488 | 0.0173 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0123 | 0.3066 | 1 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0359 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0359 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0123 | 0.3066 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0123 | 0.3066 | 0.2836 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | 0.0035 | 0.0488 | 0.5762 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Echinococcus granulosus | cathepsin l1 | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0359 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0048 | 0.0848 | 1 |
Echinococcus granulosus | cysteine protease | 0.003 | 0.0321 | 0.0321 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin l1 | 0.0048 | 0.0848 | 0.0848 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0048 | 0.0848 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.003 | 0.0321 | 0.0321 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Cathepsin L-like precursor | 0.0035 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | ctsf protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Toxoplasma gondii | cathepsin B | 0.0123 | 0.3066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0048 | 0.0848 | 0.0544 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0848 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0035 | 0.0488 | 0.0488 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0848 | 0.0848 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0048 | 0.0848 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0123 | 0.3066 | 0.3066 |
Loa Loa (eye worm) | fibroinase | 0.0048 | 0.0848 | 0.0848 |
Giardia lamblia | Cathepsin B precursor | 0.0123 | 0.3066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Echinococcus granulosus | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Echinococcus multilocularis | cathepsin L | 0.003 | 0.0321 | 0.0321 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0035 | 0.0488 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0123 | 0.3066 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Brugia malayi | Papain family cysteine protease containing protein | 0.003 | 0.0321 | 0.0321 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Loa Loa (eye worm) | cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0488 | 0.0488 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0848 | 0.0544 |
Onchocerca volvulus | 0.0048 | 0.0848 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0848 | 0.0848 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0035 | 0.0488 | 0.0611 |
Echinococcus multilocularis | cathepsin b | 0.0359 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0048 | 0.0848 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0848 | 0.1919 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0848 | 0.1919 |
Loa Loa (eye worm) | cathepsin B | 0.0123 | 0.3066 | 0.3066 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0848 | 0.0848 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0848 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 7 % | Analgesic activity in Swiss-Webster mouse assessed as reduction of acetylcholine-induced writhing at 75 mg/kg, sc relative to control | ChEMBL. | 31482 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.