Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.1279 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0.1954 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0105 | 0.1954 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.1279 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0.1954 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0105 | 0.1954 | 0.1279 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0087 | 0.1377 | 0.7045 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.07 | 0.0059 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.067 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.1279 |
Brugia malayi | Peptidase family M1 containing protein | 0.0105 | 0.1954 | 0.067 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.07 | 0.0059 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.067 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1377 | 0.0888 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.1279 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0105 | 0.1954 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0105 | 0.1954 | 0.5 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0068 | 0.0774 | 0.3962 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0105 | 0.1954 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.07 | 0.0059 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0105 | 0.1954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.07 | 0.0059 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.067 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0087 | 0.1377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.07 | 0.0059 |
Toxoplasma gondii | peptidase family M13 protein | 0.0087 | 0.1377 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0289 | 0.7824 | 0.878 |
Echinococcus multilocularis | aminopeptidase N | 0.0357 | 1 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0087 | 0.1377 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0087 | 0.1377 | 0.0653 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0105 | 0.1954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0774 | 0.015 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0105 | 0.1954 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0105 | 0.1954 | 0.5 |
Brugia malayi | hypothetical protein | 0.0105 | 0.1954 | 0.067 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0774 | 0.015 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0105 | 0.1954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1377 | 0.0888 |
Echinococcus granulosus | aminopeptidase N | 0.0357 | 1 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.067 |
Onchocerca volvulus | 0.0357 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.882 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.6644 | 0.7336 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0105 | 0.1954 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0105 | 0.1954 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1377 | 0.0888 |
Loa Loa (eye worm) | aminopeptidase N | 0.0105 | 0.1954 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.07 | 0.0059 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.1954 | 0.1279 |
Entamoeba histolytica | aminopeptidase, putative | 0.0105 | 0.1954 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30 % | Antiproliferative activity against mouse L1210 cells assessed as cell viability at 0.1 mM after 72 hrs by trypan blue dye based hemocytometer analysis relative to control | ChEMBL. | 1063272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.