Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | lipase domain protein, putative | 0.1002 | 0.5112 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1002 | 0.5112 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1002 | 0.5112 | 0.5 |
Brugia malayi | Lipase family protein | 0.1002 | 0.5112 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1002 | 0.5112 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1002 | 0.5112 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.1002 | 0.5112 | 0.5 |
Loa Loa (eye worm) | lipase | 0.1002 | 0.5112 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1002 | 0.5112 | 0.5 |
Onchocerca volvulus | 0.1002 | 0.5112 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1002 | 0.5112 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.1917 | 0.9915 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1002 | 0.5112 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 6.66 mm | Antibacterial activity against Escherichia coli ATCC 25922 assessed as diameter of growth inhibition zone at 0.25 mg/ml after 24 hrs by disk diffusion assay | ChEMBL. | 24751444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.