Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Leishmania major | cathepsin L-like protease | 0.0106 | 0.5486 | 1 |
Onchocerca volvulus | 0.0051 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0051 | 0.1575 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0051 | 0.1575 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0051 | 0.1575 | 0.113 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0036 | 0.0501 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0051 | 0.1575 | 0.1575 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0051 | 0.1575 | 0.1575 |
Brugia malayi | Cathepsin L-like precursor | 0.0051 | 0.1575 | 0.1575 |
Brugia malayi | Cathepsin L-like precursor | 0.0051 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Loa Loa (eye worm) | cysteine protease | 0.0051 | 0.1575 | 0.113 |
Echinococcus granulosus | cathepsin l1 | 0.0036 | 0.0501 | 0.0501 |
Plasmodium vivax | vivapain-2 | 0.0051 | 0.1575 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0091 | 0.4412 | 0.4412 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0051 | 0.1575 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.017 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0062 | 0.2351 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0051 | 0.1575 | 0.113 |
Giardia lamblia | Cathepsin B precursor | 0.0062 | 0.2351 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Onchocerca volvulus | 0.0051 | 0.1575 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.5486 | 0.5486 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0036 | 0.0501 | 0.0501 |
Echinococcus granulosus | cathepsin b | 0.017 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.017 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.017 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0051 | 0.1575 | 0.1575 |
Onchocerca volvulus | 0.0051 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0051 | 0.1575 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.017 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.017 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.017 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Echinococcus granulosus | cathepsin b | 0.017 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0036 | 0.0501 | 0.0501 |
Onchocerca volvulus | 0.0051 | 0.1575 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0062 | 0.2351 | 0.4286 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0051 | 0.1575 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0036 | 0.0501 | 0.0501 |
Leishmania major | cathepsin L-like protease | 0.0106 | 0.5486 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0036 | 0.0501 | 0.0501 |
Brugia malayi | Cathepsin L-like precursor | 0.0051 | 0.1575 | 0.1575 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0051 | 0.1575 | 0.1575 |
Onchocerca volvulus | Cathepsin L homolog | 0.0051 | 0.1575 | 1 |
Leishmania major | cathepsin L-like protease | 0.0106 | 0.5486 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0051 | 0.1575 | 0.113 |
Echinococcus multilocularis | cathepsin b | 0.017 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0051 | 0.1575 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0062 | 0.2351 | 0.1948 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0051 | 0.1575 | 0.1575 |
Brugia malayi | Cathepsin L-like precursor | 0.0051 | 0.1575 | 0.1575 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0106 | 0.5486 | 0.5486 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0062 | 0.2351 | 0.2351 |
Toxoplasma gondii | cathepsin B | 0.0062 | 0.2351 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0062 | 0.2351 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0051 | 0.1575 | 0.1575 |
Onchocerca volvulus | Cathepsin L homolog | 0.0051 | 0.1575 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Brugia malayi | Cathepsin L-like precursor | 0.0036 | 0.0501 | 0.0501 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0051 | 0.1575 | 0.1575 |
Onchocerca volvulus | 0.0051 | 0.1575 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Brugia malayi | Cathepsin L-like precursor | 0.0051 | 0.1575 | 0.1575 |
Brugia malayi | Cathepsin L-like precursor | 0.0051 | 0.1575 | 0.1575 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0051 | 0.1575 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0069 | 0.2838 | 0.2838 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0106 | 0.5486 | 1 |
Plasmodium vivax | vivapain-2 | 0.0051 | 0.1575 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0051 | 0.1575 | 0.1575 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.5486 | 0.5486 |
Echinococcus granulosus | cathepsin l1 | 0.0051 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Giardia lamblia | Cathepsin B precursor | 0.0062 | 0.2351 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0051 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Echinococcus multilocularis | cysteine protease | 0.0051 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0036 | 0.0501 | 0.2131 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1575 | 0.113 |
Onchocerca volvulus | Cathepsin F homolog | 0.0051 | 0.1575 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0051 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0036 | 0.0501 | 0.2131 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0051 | 0.1575 | 0.1575 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0051 | 0.1575 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0062 | 0.2351 | 0.1985 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0106 | 0.5486 | 0.5486 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0051 | 0.1575 | 0.6698 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0051 | 0.1575 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0062 | 0.2351 | 0.2351 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (binding) | = 1.6 nM | Antagonist activity at EP2 receptor (unknown origin) expressed in rat C6 cells assessed as inhibition of PGE2-induced response | ChEMBL. | 24937185 |
Stabilty (ADMET) | = 71 % | Metabolic stability of the compound in mouse liver microsomes assessed as compound remaining at 10 uM after 15 mins | ChEMBL. | 24937185 |
Stabilty (ADMET) | = 88 % | Metabolic stability of the compound in human liver microsomes assessed as compound remaining at 10 uM after 15 mins | ChEMBL. | 24937185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.