Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Mus musculus | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0077 | 0 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0332 | 1 | 1 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0332 | 1 | 1 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0332 | 1 | 0.5 |
Trichomonas vaginalis | porcupine, putative | 0.0077 | 0 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0332 | 1 | 1 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0077 | 0 | 0.5 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0098 | 0.0803 | 0.0803 |
Leishmania major | diacylglycerol acyltransferase, putative | 0.0098 | 0.0803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.6969 | 0.6969 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.0098 | 0.0803 | 0.0803 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0098 | 0.0803 | 0.0803 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0098 | 0.0803 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0077 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol acyltransferase, putative | 0.0098 | 0.0803 | 1 |
Onchocerca volvulus | 0.0098 | 0.0803 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0332 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0332 | 1 | 1 |
Trypanosoma brucei | diacylglycerol acyltransferase, putative | 0.0098 | 0.0803 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0077 | 0 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0332 | 1 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0332 | 1 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0098 | 0.0803 | 0.0803 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 nM | Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis | ChEMBL. | 24900877 |
IC50 (binding) | = 52 nM | Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting analysis | ChEMBL. | 24900877 |
Inhibition (functional) | = 2 % | Reduction in triglycerides level in mouse at 3 mg/kg, po after 2 hrs by postprandial triglyceride assay | ChEMBL. | 24900877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.