Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate after 60 mins by Ellman's method | ChEMBL. | 24835788 |
Inhibition (binding) | = 32 % | Inhibition of BChE in horse serum using butyrylthiocholine iodide as substrate at 200 uM after 120 mins by Ellman's method relative to control | ChEMBL. | 24835788 |
Inhibition (binding) | = 40.4 % | Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate at 200 uM after 60 mins by Ellman's method relative to control | ChEMBL. | 24835788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.