Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1614 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0065 | 0 | 0.5 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0146 | 0.2825 | 0.5 |
Toxoplasma gondii | PAN domain-containing protein | 0.035 | 1 | 0.5 |
Onchocerca volvulus | 0.0146 | 0.2825 | 1 | |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0146 | 0.2825 | 0.5 |
Onchocerca volvulus | 0.0146 | 0.2825 | 1 | |
Onchocerca volvulus | 0.0146 | 0.2825 | 1 | |
Onchocerca volvulus | 0.0146 | 0.2825 | 1 | |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0146 | 0.2825 | 1 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0146 | 0.2825 | 0.5 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0065 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 70.3 uM | Cytotoxicity against human DU145 cells after 48 hrs by MTT assay | ChEMBL. | 25499929 |
Inhibition (binding) | = 16 % | Inhibition of bovine brain tubulin polymerization at 10 uM measured for 1 hr by fluorescence assay | ChEMBL. | 25499929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.