Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | bromodomain-containing protein | 0.507 | 0.3184 | 0.5 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 1.1279 | 1 | 1 |
Loa Loa (eye worm) | CBP-B | 0.3954 | 0.1958 | 0.1958 |
Entamoeba histolytica | bromodomain-containing protein | 0.507 | 0.3184 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6209 | 0.4434 | 0.1834 |
Toxoplasma gondii | bromodomain-containing protein | 0.507 | 0.3184 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.5365 | 0.3508 | 0.2305 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 1.1279 | 1 | 1 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.7034 | 0.534 | 0.3163 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 1.1279 | 1 | 1 |
Echinococcus multilocularis | Bromodomain containing protein | 0.507 | 0.3184 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 1.1279 | 1 | 1 |
Onchocerca volvulus | 0.507 | 0.3184 | 0.5 | |
Brugia malayi | Bromodomain containing protein | 1.1279 | 1 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.507 | 0.3184 | 0.3184 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.7034 | 0.534 | 0.3163 |
Trichomonas vaginalis | conserved hypothetical protein | 0.7034 | 0.534 | 0.3163 |
Echinococcus multilocularis | bromodomain containing 2 | 1.1279 | 1 | 1 |
Echinococcus granulosus | bromodomain containing 2 | 1.1279 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.7034 | 0.534 | 0.3163 |
Giardia lamblia | Kinase, putative | 0.507 | 0.3184 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.7034 | 0.534 | 0.3163 |
Brugia malayi | TAZ zinc finger family protein | 0.5365 | 0.3508 | 0.1593 |
Entamoeba histolytica | bromodomain-containing protein | 0.507 | 0.3184 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.699 | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
IC50 (binding) | = 200 uM | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.