Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | macrophage expressed 1 | Starlite/ChEMBL | References |
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0142 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.012 | 0.4684 | 0.4684 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 57.6 % | Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as remaining activity by measuring lipoxygenase products formation at 10 uM pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay | ChEMBL. | 25765759 |
Activity (binding) | = 66.8 % | Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as remaining activity by measuring lipoxygenase products formation at 10 uM in presence of arachidonic acid pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay | ChEMBL. | 25765759 |
Activity (binding) | = 88.9 % | Inhibition of 12-LOX in human blood PMNL assessed as remaining activity by measuring 12-HETE synthesis at 10 uM | ChEMBL. | 25765759 |
Activity (binding) | = 97.3 % | Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as assessed as remaining PGE2 synthase activity at 10 uM after 15 mins using PGH2 substrate by RP-HPLC method | ChEMBL. | 25765759 |
Activity (binding) | = 114.8 % | Inhibition of 15-LOX-1 in human blood PMNL assessed as remaining activity by measuring 15-HETE synthesis at 10 uM | ChEMBL. | 25765759 |
IC50 (binding) | = 0.62 uM | Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-free assay | ChEMBL. | 25765759 |
IC50 (binding) | > 10 uM | Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay | ChEMBL. | 25765759 |
IC50 (binding) | > 10 uM | Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pre-incubated for 15 mins followed by stimulation with A23187 for 10 mins by RP-HPLC based cell based assay | ChEMBL. | 25765759 |
IC50 (binding) | > 10 uM | Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using PGH2 substrate by RP-HPLC method | ChEMBL. | 25765759 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.