TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.842 | Formula: C19H13ClFN3OS
H donors: 1 H acceptors: 2 LogP: 5.79 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1c1sc2c(c1)c(ncn2)Nc1ccc(c(c1)Cl)F
InChi: 1S/C19H13ClFN3OS/c1-25-16-5-3-2-4-12(16)17-9-13-18(22-10-23-19(13)26-17)24-11-6-7-15(21)14(20)8-11/h2-10H,1H3,(H,22,23,24)
InChiKey: DDDGSLANZIDSLT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	neuropeptides capa receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	beta-tubulin	0.0162	0.8515	0.8515
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0116	0.4789	0.4789
Echinococcus multilocularis	allatostatin A receptor	0.0116	0.4789	0.4789
Brugia malayi	sulfakinin receptor protein	0.0116	0.4789	0.4789
Schistosoma mansoni	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	biogenic amine 5HT receptor	0.0116	0.4789	0.4789
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0116	0.4789	0.4789
Schistosoma mansoni	tyrosine kinase	0.0096	0.3117	0.3117
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	amine GPCR	0.0116	0.4789	0.4789
Schistosoma mansoni	neuropeptide F-like receptor	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Schistosoma mansoni	hypothetical protein	0.0116	0.4789	0.4789
Entamoeba histolytica	tubulin family protein	0.0162	0.8515	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0116	0.4789	0.4789
Echinococcus multilocularis	neuropeptide receptor	0.0116	0.4789	0.4789
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0116	0.4789	0.4789
Echinococcus granulosus	tm gpcr rhodopsin	0.0116	0.4789	0.4789
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	tubulin beta 1 chain	0.0162	0.8515	0.8515
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Brugia malayi	ORL1-like opioid receptor	0.0116	0.4789	0.4789
Brugia malayi	putative neuropeptide receptor NPR1	0.0116	0.4789	0.4789
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0116	0.4789	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	epidermal growth factor receptor	0.018	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Brugia malayi	Dopamine receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0116	0.4789	0.4789
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0116	0.4789	0.4789
Echinococcus granulosus	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Trypanosoma brucei	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	G protein coupled receptor 139	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0116	0.4789	0.4789
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0116	0.4789	0.4789
Schistosoma mansoni	tubulin subunit beta	0.0162	0.8515	0.8515
Trichomonas vaginalis	tubulin alpha chain, putative	0.0162	0.8515	0.5
Brugia malayi	Serotonin receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	tubulin beta chain	0.0162	0.8515	0.8515
Echinococcus granulosus	neuropeptide FF receptor 2	0.0116	0.4789	0.4789
Echinococcus granulosus	tubulin subunit beta	0.0162	0.8515	0.8515
Brugia malayi	Dopamine receptor protein 2	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Echinococcus granulosus	serotonin receptor	0.0116	0.4789	0.4789
Brugia malayi	RE15519p	0.0116	0.4789	0.4789
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0116	0.4789	0.4789
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0162	0.8515	0.5
Echinococcus granulosus	allatostatin A receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	opsin-like receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Schistosoma mansoni	neuropeptide receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	sex peptide receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Echinococcus multilocularis	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Echinococcus granulosus	tubulin beta 4A class IVa	0.0162	0.8515	0.8515
Schistosoma mansoni	adenoreceptor	0.0116	0.4789	0.4789
Echinococcus granulosus	somatostatin receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	orexin receptor type 2	0.0116	0.4789	0.4789
Echinococcus multilocularis	neuropeptide receptor A26	0.0116	0.4789	0.4789
Echinococcus multilocularis	beta tubulin	0.0162	0.8515	0.8515
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	biogenic amine receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	tubulin subunit beta	0.0162	0.8515	0.8515
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Trypanosoma brucei	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Echinococcus multilocularis	epidermal growth factor receptor	0.018	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	g protein coupled receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0116	0.4789	0.4789
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0116	0.4789	0.4789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Trichomonas vaginalis	tubulin beta chain, putative	0.0162	0.8515	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0162	0.8515	0.8515
Echinococcus multilocularis	serotonin receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.32	0.32
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	neuropeptide receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	G-protein coupled receptor	0.0116	0.4789	0.4789
Toxoplasma gondii	beta-tubulin, putative	0.0162	0.8515	0.5
Schistosoma mansoni	tyrosine kinase	0.0097	0.32	0.32
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0116	0.4789	0.4789
Schistosoma mansoni	neuropeptide receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	dro:myosuppressin receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0116	0.4789	0.4789
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	neuropeptide Y receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	tm gpcr rhodopsin	0.0116	0.4789	0.4789
Brugia malayi	GnHR receptor homolog	0.0116	0.4789	0.4789
Echinococcus granulosus	neuropeptide receptor A26	0.0116	0.4789	0.4789
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0116	0.4789	0.4789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	tyrosine kinase	0.0096	0.3117	0.3117
Loa Loa (eye worm)	melatonin receptor type 1A	0.0116	0.4789	0.4789
Echinococcus multilocularis	tubulin subunit beta	0.0162	0.8515	0.8515
Trichomonas vaginalis	tubulin gamma chain, putative	0.0162	0.8515	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	tubulin beta-4 chain	0.0162	0.8515	0.8515
Onchocerca volvulus		0.0116	0.4789	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0116	0.4789	0.4789
Giardia lamblia	Beta tubulin	0.0162	0.8515	0.5
Echinococcus granulosus	g protein coupled receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	tubulin subunit beta	0.0162	0.8515	0.8515
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0116	0.4789	0.4789
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0162	0.8515	0.5
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0116	0.4789	0.4789
Brugia malayi	larval opioid receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Brugia malayi	Serotonin receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0116	0.4789	0.4789
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.32	0.32
Toxoplasma gondii	beta tubulin	0.0162	0.8515	0.5
Brugia malayi	AKH receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	neuropeptide receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	opsin-like receptor	0.0116	0.4789	0.4789
Toxoplasma gondii	beta-1 tubulin, putative	0.0162	0.8515	0.5
Schistosoma mansoni	amine GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	follicle stimulating hormone receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Echinococcus multilocularis	somatostatin receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	BEN-1 protein	0.0162	0.8515	0.8515
Schistosoma mansoni	neuropeptide f receptor 76f	0.0116	0.4789	0.4789
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0116	0.4789	0.4789
Trypanosoma cruzi	beta tubulin, putative	0.0162	0.8515	0.5
Onchocerca volvulus		0.0116	0.4789	0.5
Schistosoma mansoni	amine GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0116	0.4789	0.4789
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	amine GPCR	0.0116	0.4789	0.4789
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	myosin xvIII	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	tubulin subunit beta	0.0162	0.8515	0.8515
Schistosoma mansoni	growth hormone secretagogue receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Echinococcus granulosus	neuropeptide Y receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus granulosus	beta tubulin	0.0162	0.8515	0.8515
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	g-protein coupled receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Onchocerca volvulus		0.0116	0.4789	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	7TM GPCR rhodopsin	0.0116	0.4789	0.4789
Loa Loa (eye worm)	tubulin beta-2A chain	0.0162	0.8515	0.8515
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0116	0.4789	0.4789
Schistosoma mansoni	biogenic amine receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Onchocerca volvulus		0.0116	0.4789	0.5
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	amine GPCR	0.0116	0.4789	0.4789
Echinococcus multilocularis	neuropeptide receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Plasmodium falciparum	tubulin beta chain	0.0162	0.8515	0.5
Schistosoma mansoni	neuropeptide receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	sex peptide receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	tyrosine kinase	0.018	1	1
Brugia malayi	neuropeptide F receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	tubulin beta-1 chain	0.0162	0.8515	0.8515
Echinococcus multilocularis	fmrfamide receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	neuropeptides capa receptor	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Schistosoma mansoni	histamine h1 receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	dro:myosuppressin receptor	0.0116	0.4789	0.4789
Giardia lamblia	Beta tubulin	0.0162	0.8515	0.5
Giardia lamblia	Beta tubulin	0.0162	0.8515	0.5
Brugia malayi	Dopamine receptor protein 1	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Entamoeba histolytica	tubulin family protein	0.0162	0.8515	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0116	0.4789	0.4789
Loa Loa (eye worm)	neuropeptide F receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0116	0.4789	0.4789
Brugia malayi	putative neuropeptide receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	beta tubulin	0.0162	0.8515	0.8515
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	tyrosine kinase	0.0096	0.3117	0.3117
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Onchocerca volvulus		0.0116	0.4789	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.32	0.32
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	G-protein coupled receptor	0.0116	0.4789	0.4789
Plasmodium vivax	tubulin beta chain, putative	0.0162	0.8515	0.5
Onchocerca volvulus		0.0116	0.4789	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	tubulin subunit beta	0.0162	0.8515	0.8515
Brugia malayi	Melatonin receptor type 1A	0.0116	0.4789	0.4789
Schistosoma mansoni	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	opsin-like receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0116	0.4789	0.4789
Echinococcus granulosus	g protein coupled receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Brugia malayi	G protein-coupled receptor	0.0116	0.4789	0.4789
Trypanosoma brucei	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Echinococcus multilocularis	serotonin receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	tubulin beta 1 chain	0.0162	0.8515	0.8515
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	G-protein coupled receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0116	0.4789	0.4789
Brugia malayi	neuropeptide F receptor	0.0116	0.4789	0.4789
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0116	0.4789	0.4789
Echinococcus multilocularis	orexin receptor type 2	0.0116	0.4789	0.4789
Brugia malayi	G-protein coupled receptor	0.0116	0.4789	0.4789
Brugia malayi	G protein-coupled receptor F59B2.13	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	Tubulin beta-1 chain	0.0162	0.8515	0.8515
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0116	0.4789	0.4789
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Echinococcus multilocularis	neuropeptide s receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	tyrosine kinase	0.0097	0.32	0.32
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0116	0.4789	0.4789
Echinococcus granulosus	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0116	0.4789	0.4789
Echinococcus granulosus	7tm_1 domain containing protein	0.0116	0.4789	0.4789
Echinococcus granulosus	neuropeptide receptor	0.0116	0.4789	0.4789
Leishmania major	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	BEN-1 protein	0.0162	0.8515	0.8515
Trypanosoma brucei	beta tubulin	0.0162	0.8515	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus granulosus	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Schistosoma mansoni	tubulin subunit beta	0.0162	0.8515	0.8515
Loa Loa (eye worm)	TYRA-2 protein	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Onchocerca volvulus		0.0116	0.4789	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	g protein coupled receptor	0.0116	0.4789	0.4789
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	fmrfamide receptor	0.0116	0.4789	0.4789
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0116	0.4789	0.4789
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0116	0.4789	0.4789
Echinococcus multilocularis	beta tubulin	0.0162	0.8515	0.8515
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0116	0.4789	0.4789
Echinococcus multilocularis	Tubulin beta 2C chain	0.0162	0.8515	0.8515
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0116	0.4789	0.5
Schistosoma mansoni	biogenic amine receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Brugia malayi	hypothetical protein	0.0116	0.4789	0.4789
Echinococcus multilocularis	neuropeptides capa receptor	0.0116	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Echinococcus granulosus	g protein coupled receptor	0.0116	0.4789	0.4789
Echinococcus granulosus	fmrfamide receptor	0.0116	0.4789	0.4789
Brugia malayi	beta-tubulin, identical	0.0162	0.8515	0.8515
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0116	0.4789	0.4789
Onchocerca volvulus		0.0116	0.4789	0.5
Trichomonas vaginalis	tubulin, putative	0.0162	0.8515	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5 nM	Inhibition of EGFR (unknown origin) by Z'-LYTE assay	ChEMBL.	25768701
Inhibition (binding)	= 92 %	Inhibition of EGFR (unknown origin) at 100 nM by Z'-LYTE assay relative to control	ChEMBL.	25768701

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3416625

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1930764