Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2365 | 0.4828 |
Plasmodium falciparum | plasmepsin VI | 0.0054 | 0.0212 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0104 | 0.49 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0054 | 0.0212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2534 | 0.5172 |
Toxoplasma gondii | peptidase family M13 protein | 0.0104 | 0.49 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2365 | 0.4828 |
Plasmodium vivax | plasmepsin IV, putative | 0.0054 | 0.0212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2534 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0212 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2534 | 0.5172 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0104 | 0.49 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0054 | 0.0212 | 0.0125 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0054 | 0.0212 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0104 | 0.49 | 0.4854 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.49 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.49 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0104 | 0.49 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2534 | 0.5172 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0104 | 0.49 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0104 | 0.49 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0054 | 0.0212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2534 | 0.5172 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0104 | 0.49 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2534 | 0.5172 |
Brugia malayi | Peptidase family M13 containing protein | 0.0104 | 0.49 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0077 | 0.2365 | 0.4828 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0158 | 1 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0054 | 0.0212 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0054 | 0.0212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2365 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2365 | 0.4828 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0077 | 0.2365 | 0.4828 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0054 | 0.0212 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.49 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 31 nM | Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometry | ChEMBL. | 25666912 |
Ratio (binding) | = 0.7 | Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membrane assessed as kinetic rate index at Ki by dual-point competition association assay relative to control | ChEMBL. | 25666912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.